Glycolysis and gluconeogenesis (WP534)

Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH. Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol, glucogenic amino acids, and fatty acids. Description adapted from [http://www.wikipedia.org Wikipedia]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP534 CPTAC Assay Portal]
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Authors

Kdahlquist, MaintBot, Susan, N.Fidelman, MartijnVanIersel, Khanspers, Thomas, Jildau, AlexanderPico, Egonw, Mkutmon, The Herald, MirkoBaranzini, DeSl, MarkAHershberger, Ambar21, and Eweitz

Cited In

Organism

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology: citric acid cycle pathway gluconeogenesis pathway glycolysis/gluconeogenesis pathway

Participants

Label Type Compact Identifier
TPI1 GeneProduct ncbigene:7167
Malate Metabolite hmdb:HMDB0000744
PFKP GeneProduct ncbigene:5214
2P-Glycerate Metabolite hmdb:HMDB0000362
FBP1 GeneProduct ncbigene:2203
ALDOA GeneProduct ncbigene:226
LDHAL6B GeneProduct ncbigene:92483
Pentose Phosphate Pathway Pathway wikipathways:WP134
PKM1 GeneProduct ncbigene:5315
ALDOC GeneProduct ncbigene:230
SLC2A2 GeneProduct ncbigene:6514
GOT1 GeneProduct ncbigene:2805
Oxaloacetate Metabolite hmdb:HMDB0000223
GAPDH GeneProduct ensembl:ENSG00000111640
DLD GeneProduct ncbigene:1738
1,3BP-Glycerate Metabolite hmdb:HMDB0001270
PC GeneProduct ncbigene:5091
Oxaloacetate Metabolite hmdb:HMDB0000223
Acetyl-CoA Metabolite hmdb:HMDB0001206
PFKM GeneProduct ncbigene:5213
GOT2 GeneProduct ncbigene:2806
PGK1 GeneProduct ncbigene:5230
3P-Glycerate Metabolite hmdb:HMDB0000807
MDH1 GeneProduct ncbigene:4190
PKLR GeneProduct ncbigene:5313
SLC2A5 GeneProduct ncbigene:6518
PDHA1 GeneProduct ncbigene:5160
MDH2 GeneProduct ncbigene:4191
LDHA GeneProduct ncbigene:3939
Fructose-1,6BP Metabolite hmdb:HMDB0001058
HK1 GeneProduct ncbigene:3098
Lactate Metabolite hmdb:HMDB0000190
SLC2A1 GeneProduct ncbigene:6513
PGAM2 GeneProduct ncbigene:5224
DLAT GeneProduct ncbigene:1737
PFKL GeneProduct ncbigene:5211
Glucose Metabolite hmdb:HMDB0000122
ENO3 GeneProduct ncbigene:2027
ENO1 GeneProduct ncbigene:2023
Glyceraldehyde 3P Metabolite hmdb:HMDB0001112
Pyruvate Metabolite hmdb:HMDB0000243
LDHC GeneProduct ncbigene:3948
HK3 GeneProduct ncbigene:3101
Pyruvate Metabolite hmdb:HMDB0000243
Fructose 6P Metabolite chebi:61527
Malate Metabolite hmdb:HMDB0000744
Glucose Metabolite hmdb:HMDB0000122
LDHB GeneProduct ncbigene:3945
Triglyceride synthesis Pathway wikipathways:WP325
MPC2 GeneProduct ncbigene:25874
MPC1 GeneProduct ncbigene:51660
ENO2 GeneProduct ncbigene:2026
Glycogen metabolism Pathway wikipathways:WP500
G6PC GeneProduct ncbigene:2538
HK2 GeneProduct ncbigene:3099
PCK1 GeneProduct ncbigene:5105
PGK2 GeneProduct ncbigene:5232
Aspartate Metabolite hmdb:HMDB0000191
SLC2A4 GeneProduct ncbigene:6517
Dihydroxyacetone-P Metabolite hmdb:HMDB0001473
P-enolpyruvate Metabolite hmdb:HMDB0000263
FBP2 GeneProduct ncbigene:8789
Aspartate Metabolite hmdb:HMDB0000191
SLC2A3 GeneProduct ncbigene:6515
Glucose-6P Metabolite chebi:75052
GCK GeneProduct ncbigene:2645
PGAM1 GeneProduct ncbigene:5223
PKM2 GeneProduct ncbigene:5315
TCA Cycle Pathway wikipathways:WP78
ALDOB GeneProduct ncbigene:229
Glucose-6P (open) Metabolite chebi:57584
PGI GeneProduct eccode:5.3.1.9
Fructose 6P (open) Metabolite chebi:57579
GPI GeneProduct ncbigene:2821

References

  1. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen Y-C, et al. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science. 2012 Jul 6;337(6090):96–100. PubMed Europe PMC Scholia