Exercise-induced circadian regulation (WP544)

Time- and exercise-dependent gene regulation in human skeletal muscle, http://genomebiology.com/2003/4/10/R61 Mouse genes regulated in the diurnal (inferred from human) and compared with mouse genes that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regulated (P < 0.05) hSkM genes identified in the diurnal comparison (0800 h and 2000 h) were subjected to an additional statistical filter of absolute fold change > 20% (n = 239) and linked to mouse circadianly regulated orthologues. This pathway represents the resultant 44 putative hSkM circadianly regulated genes; L, promoter for the light-responsive element; E, E-box (Clock/Bmal1 promoter). Orthologue information is denoted to the left of the gene boxes: mHrts and mLvrs, mouse orthologue was circadianly regulated as described (Storch 2002) in mouse heart or liver, respectively; mLvrp and mSCNp, mouse orthologue was diurnally regulated as described (Panda 2002) in mouse liver or SCN, respectively.
last edited


A.C.Zambon, MaintBot, Evelo, Khanspers, Mkutmon, AlexanderPico, Susan, and Eweitz

Cited In


Mus musculus



Pathway Ontology: regulatory pathway

Cell Type Ontology: skeletal muscle fiber skeletal muscle fiber


Label Type Compact Identifier
Ucp3 GeneProduct ncbigene:22229
Vapa GeneProduct ncbigene:30960
Arntl GeneProduct ncbigene:11865
Sumo3 GeneProduct ncbigene:20610
Per2 GeneProduct ncbigene:18627
Cebpb GeneProduct ncbigene:12608
Zfr GeneProduct ncbigene:22763
Pigf GeneProduct ncbigene:18701
Gstm3 GeneProduct ncbigene:14864
Sf3a3 GeneProduct ncbigene:75062
Hist1h2bn GeneProduct ncbigene:319187
Cry1 GeneProduct ncbigene:12952
Tob1 GeneProduct ncbigene:22057
Oazin GeneProduct ncbigene:54375
Pura GeneProduct ncbigene:19290
D5Ertd593e GeneProduct ncbigene:52331
Herpud1 GeneProduct ncbigene:64209
Ppp2cb GeneProduct ncbigene:19053
Cldn5 GeneProduct ncbigene:12741
Nr1d2 GeneProduct ncbigene:353187
G0s2 GeneProduct ncbigene:14373
Eif4g2 GeneProduct ncbigene:13690
Cry2 GeneProduct ncbigene:12953
Clock GeneProduct ncbigene:12753
Myf6 GeneProduct ncbigene:17878
Nckap1 GeneProduct ncbigene:50884
Dnaja1 GeneProduct ncbigene:15502
Nr1d1 GeneProduct ncbigene:217166
Cbx3 GeneProduct ncbigene:12417
Ncoa4 GeneProduct ncbigene:27057
Ppp1r3c GeneProduct ncbigene:53412
Etv6 GeneProduct ncbigene:14011
Ugp2 GeneProduct ncbigene:216558
Per1 GeneProduct ncbigene:18626
D14Ertd171e GeneProduct ncbigene:238988
Tubb4 GeneProduct ncbigene:22153
Dazap2 GeneProduct ncbigene:23994
Gstp2 GeneProduct ncbigene:14869
Qk GeneProduct ncbigene:19317
Hspa8 GeneProduct ncbigene:15481
Map3k7ip2 GeneProduct ncbigene:68652
Psma4 GeneProduct ncbigene:26441
Gfra1 GeneProduct ncbigene:14585
H2-DMa GeneProduct ncbigene:14998
Bteb1 GeneProduct ncbigene:16601
Btg1 GeneProduct ncbigene:12226
Rbpms GeneProduct ncbigene:19663
Sumo1 GeneProduct ncbigene:22218
Idi1 GeneProduct ncbigene:319554


  1. Zambon AC, McDearmon EL, Salomonis N, Vranizan KM, Johansen KL, Adey D, et al. Time- and exercise-dependent gene regulation in human skeletal muscle. Genome Biol. 2003;4(10):R61. PubMed Europe PMC Scholia