Eukaryotic transcription initiation (WP567)

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: [[wikipedia:Transcription_(genetics)|Wikipedia]]
last edited

Authors

Nsalomonis, MaintBot, AlexanderPico, Khanspers, Thomas, Christine Chichester, Mkutmon, and Eweitz

Cited In

Organism

Mus musculus

Communities

Annotations

Pathway Ontology: transcription pathway

Participants

Label Type Compact Identifier
Gtf2a2 GeneProduct ncbigene:235459
Taf7 GeneProduct ncbigene:24074
Ercc3 GeneProduct ncbigene:13872
Gtf2f2 GeneProduct ncbigene:68705
Gtf2b GeneProduct ncbigene:229906
Polr2f GeneProduct ncbigene:110812
Gtf2h2 GeneProduct ncbigene:23894
Polr2g GeneProduct ncbigene:67710
Taf9 GeneProduct ncbigene:108143
Polr2j GeneProduct ncbigene:20022
Gtf2e2 GeneProduct ncbigene:68153
Gtf2e1 GeneProduct ncbigene:74197
Polr2h GeneProduct ncbigene:245841
Polr3d GeneProduct ncbigene:67065
Rpo1-4 GeneProduct ncbigene:20019
Gtf2h3 GeneProduct ncbigene:209357
Taf13 GeneProduct ncbigene:99730
Polr3e GeneProduct ncbigene:26939
Rpo1-1 GeneProduct ncbigene:20016
Taf6 GeneProduct ncbigene:21343
Taf12 GeneProduct ncbigene:66464
Ilk GeneProduct ncbigene:16202
Rpo1-3 GeneProduct ncbigene:20018
Polr2k GeneProduct ncbigene:17749
Polr2a GeneProduct ncbigene:20020
Polr2i GeneProduct ncbigene:69920
Gtf2h1 GeneProduct ncbigene:14884
Polr3h GeneProduct ncbigene:78929
Ccnh GeneProduct ncbigene:66671
Cdk7 GeneProduct ncbigene:12572
Rpo1-2 GeneProduct ncbigene:20017
Taf5 GeneProduct ncbigene:226182
Polr3k GeneProduct ncbigene:67005
Polr2e GeneProduct ncbigene:66420
Tbp GeneProduct ncbigene:21374
Polr3b GeneProduct ncbigene:70428
Polr2b GeneProduct ncbigene:231329
Gtf2h4 GeneProduct ncbigene:14885
Mnat1 GeneProduct ncbigene:17420
Polr2c GeneProduct ncbigene:20021
Ercc2 GeneProduct ncbigene:13871

References

  1. Lee TI, Young RA. Regulation of gene expression by TBP-associated proteins. Genes Dev. 1998 May 15;12(10):1398–408. PubMed Europe PMC Scholia
  2. Lemon B, Tjian R. Orchestrated response: a symphony of transcription factors for gene control. Genes Dev. 2000 Oct 15;14(20):2551–69. PubMed Europe PMC Scholia