IL-2 signaling pathway (WP569)

IL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions related to B cell proliferation, and cytolytic activity of natural killer cells. IL-2 also activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation-induced cell death. More recently, IL-2 was shown to promote tolerance through its effects on regulatory T cell development. IL-2 clinically has anti-cancer effects as well as utility in supporting T cell numbers in HIV/AIDS. There are three classes of IL-2 receptors, binding IL-2 with low, intermediate, or high-affinity. The low affinity receptor (IL-2Rα alone) is not functional; signaling by IL-2 involves either the high affinity hetero-trimeric receptor containing IL-2Rα, IL-2Rβ and the common cytokine receptor gamma chain (originally named IL-2Rγ and now generally denoted as γc) or the intermediate affinity heterodimeric receptor composed of IL-2Rβ and γc. IL-2 stimulation induces the activation of the Janus family tyrosine kinases JAK1 and JAK3, which associate with IL-2Rβ and γc, respectively. These kinases in turn phosphorylate IL-2Rβ and induce tyrosine phosphorylation of STATs (signal transducers and activators of transcription) and various other downstream targets. The downstream signaling pathways activated by IL-2 also involves mitogen-activated protein kinase and phosphoinositide 3-kinase signaling modules, leading to both mitogenic and anti-apoptotic signals. Please access this pathway at [ NetSlim] database. NetPath is a collaborative project between PandeyLab at Johns Hopkins University ( and the Institute of Bioinformatics ( If you use this pathway, please cite the NetPath website until the pathway is published.
last edited


A.Pandey, MaintBot, Christine Chichester, Mkutmon, Egonw, and Eweitz

Cited In


Rattus norvegicus



Pathway Ontology: interleukin-2 signaling pathway


Label Type Compact Identifier
Il2 GeneProduct ncbigene:116562
Stat5b GeneProduct ncbigene:25126
Jak3 GeneProduct ncbigene:25326
Crk GeneProduct ncbigene:54245
Vav1 GeneProduct ncbigene:25156
Stat1 GeneProduct ncbigene:25124
Creb1 GeneProduct ncbigene:81646
Ets2 GeneProduct ncbigene:304063
Lyn GeneProduct ncbigene:81515
Akt1 GeneProduct ncbigene:24185
Tert GeneProduct ncbigene:301965
Cish GeneProduct ncbigene:83681
Ets1 GeneProduct ncbigene:24356
Ptpn11 GeneProduct ncbigene:25622
Gnb2l1 GeneProduct ncbigene:83427
Socs1 GeneProduct ncbigene:252971
Stat5a GeneProduct ncbigene:24918
SHB GeneProduct None
Pik3cd GeneProduct ncbigene:366508
Eif4e GeneProduct ncbigene:117045
Cbl GeneProduct ncbigene:500985
Stam GeneProduct ncbigene:498798
Lck GeneProduct ncbigene:313050
IL2RB GeneProduct ncbigene:25746
Il2ra GeneProduct ncbigene:25704
Raf1 GeneProduct ncbigene:24703
Cd53 GeneProduct ncbigene:24251
Icam1 GeneProduct ncbigene:25464
Il2 GeneProduct ncbigene:116562
Mtor GeneProduct ncbigene:56718
Akt1 GeneProduct ncbigene:24185
Eif3s9 GeneProduct ncbigene:288516
Jak1 GeneProduct ncbigene:84598
Grb2 GeneProduct ncbigene:81504
Tert GeneProduct ncbigene:301965
Map2k1 GeneProduct ncbigene:170851
Syk GeneProduct ncbigene:25155
Bcl2 GeneProduct ncbigene:24224
Mknk1 GeneProduct ncbigene:500526
Stat5a GeneProduct ncbigene:24918
Crk GeneProduct ncbigene:54245
Pik3r1 GeneProduct ncbigene:25513
Socs3 GeneProduct ncbigene:89829
IFNA1 GeneProduct ncbigene:298210
Pik3cb GeneProduct ncbigene:85243
Itm2b GeneProduct ncbigene:290364
Mapk8 GeneProduct ncbigene:116554
Akt1 GeneProduct ncbigene:24185
Gab2 GeneProduct ncbigene:84477
Stat3 GeneProduct ncbigene:25125
Chuk GeneProduct ncbigene:309361
Ptk2b GeneProduct ncbigene:50646
Jak2 GeneProduct ncbigene:24514
Ybx1 GeneProduct ncbigene:500538
Pik3r2 GeneProduct ncbigene:29741
Nr3c1 GeneProduct ncbigene:24413
Plcb1 GeneProduct ncbigene:24654
Rela GeneProduct ncbigene:309165
Il2 GeneProduct ncbigene:116562
PIK3CA GeneProduct ncbigene:170911
Il2rg GeneProduct ncbigene:140924
Stam2 GeneProduct ncbigene:311030
Nfkb1 GeneProduct ncbigene:81736
Prkcz GeneProduct ncbigene:25522
Il2 GeneProduct ncbigene:116562
Stat5b GeneProduct ncbigene:25126
Map2k2 GeneProduct ncbigene:58960
Nmi GeneProduct ncbigene:311021
Fyn GeneProduct ncbigene:25150
Kras GeneProduct ncbigene:24525
Mapk9 GeneProduct ncbigene:50658
Mapkapk2 GeneProduct ncbigene:289014
Mapk1 GeneProduct ncbigene:116590
Ybx1 GeneProduct ncbigene:500538
Rps6kb1 GeneProduct ncbigene:83840
Pik3cg GeneProduct ncbigene:298947
Il2 GeneProduct ncbigene:116562
Raf1 GeneProduct ncbigene:24703
Crkl GeneProduct ncbigene:287942
Mapk1 GeneProduct ncbigene:116590
Sos1 GeneProduct ncbigene:313845
Nfkb1 GeneProduct ncbigene:81736
Mapk14 GeneProduct ncbigene:81649
Hsp90aa1 GeneProduct ncbigene:299331
Mapk3 GeneProduct ncbigene:50689
Irs1 GeneProduct ncbigene:25467
Foxo3 GeneProduct ncbigene:294515
Rela GeneProduct ncbigene:309165
Mapk3 GeneProduct ncbigene:50689
Ptpn6 GeneProduct ncbigene:116689
Shc1 GeneProduct ncbigene:85385
Irs2 GeneProduct ncbigene:29376


  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. NetPath: a public resource of curated signal transduction pathways. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia