IL-2 signaling pathway (WP569)

IL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions related to B cell proliferation, and cytolytic activity of natural killer cells. IL-2 also activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation-induced cell death. More recently, IL-2 was shown to promote tolerance through its effects on regulatory T cell development. IL-2 clinically has anti-cancer effects as well as utility in supporting T cell numbers in HIV/AIDS. There are three classes of IL-2 receptors, binding IL-2 with low, intermediate, or high-affinity. The low affinity receptor (IL-2Rα alone) is not functional; signaling by IL-2 involves either the high affinity hetero-trimeric receptor containing IL-2Rα, IL-2Rβ and the common cytokine receptor gamma chain (originally named IL-2Rγ and now generally denoted as γc) or the intermediate affinity heterodimeric receptor composed of IL-2Rβ and γc. IL-2 stimulation induces the activation of the Janus family tyrosine kinases JAK1 and JAK3, which associate with IL-2Rβ and γc, respectively. These kinases in turn phosphorylate IL-2Rβ and induce tyrosine phosphorylation of STATs (signal transducers and activators of transcription) and various other downstream targets. The downstream signaling pathways activated by IL-2 also involves mitogen-activated protein kinase and phosphoinositide 3-kinase signaling modules, leading to both mitogenic and anti-apoptotic signals. Please access this pathway at [http://www.netpath.org/netslim/IL_2_pathway.html NetSlim] database. NetPath is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, please cite the NetPath website until the pathway is published.
last edited

Authors

A.Pandey, MaintBot, Christine Chichester, Mkutmon, Egonw, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: interleukin-2 signaling pathway

Participants

Label Type Compact Identifier
Il2 GeneProduct ncbigene:116562
Stat5b GeneProduct ncbigene:25126
Jak3 GeneProduct ncbigene:25326
Crk GeneProduct ncbigene:54245
Vav1 GeneProduct ncbigene:25156
Stat1 GeneProduct ncbigene:25124
Creb1 GeneProduct ncbigene:81646
Ets2 GeneProduct ncbigene:304063
Lyn GeneProduct ncbigene:81515
Akt1 GeneProduct ncbigene:24185
Tert GeneProduct ncbigene:301965
Cish GeneProduct ncbigene:83681
Ets1 GeneProduct ncbigene:24356
Ptpn11 GeneProduct ncbigene:25622
Gnb2l1 GeneProduct ncbigene:83427
Socs1 GeneProduct ncbigene:252971
Stat5a GeneProduct ncbigene:24918
SHB GeneProduct None
Pik3cd GeneProduct ncbigene:366508
Eif4e GeneProduct ncbigene:117045
Cbl GeneProduct ncbigene:500985
Stam GeneProduct ncbigene:498798
Lck GeneProduct ncbigene:313050
IL2RB GeneProduct ncbigene:25746
Il2ra GeneProduct ncbigene:25704
Raf1 GeneProduct ncbigene:24703
Cd53 GeneProduct ncbigene:24251
Icam1 GeneProduct ncbigene:25464
Il2 GeneProduct ncbigene:116562
Mtor GeneProduct ncbigene:56718
Akt1 GeneProduct ncbigene:24185
Eif3s9 GeneProduct ncbigene:288516
Jak1 GeneProduct ncbigene:84598
Grb2 GeneProduct ncbigene:81504
Tert GeneProduct ncbigene:301965
Map2k1 GeneProduct ncbigene:170851
Syk GeneProduct ncbigene:25155
Bcl2 GeneProduct ncbigene:24224
Mknk1 GeneProduct ncbigene:500526
Stat5a GeneProduct ncbigene:24918
Crk GeneProduct ncbigene:54245
Pik3r1 GeneProduct ncbigene:25513
Socs3 GeneProduct ncbigene:89829
IFNA1 GeneProduct ncbigene:298210
Pik3cb GeneProduct ncbigene:85243
Itm2b GeneProduct ncbigene:290364
Mapk8 GeneProduct ncbigene:116554
Akt1 GeneProduct ncbigene:24185
Gab2 GeneProduct ncbigene:84477
Stat3 GeneProduct ncbigene:25125
Chuk GeneProduct ncbigene:309361
Ptk2b GeneProduct ncbigene:50646
Jak2 GeneProduct ncbigene:24514
Ybx1 GeneProduct ncbigene:500538
Pik3r2 GeneProduct ncbigene:29741
Nr3c1 GeneProduct ncbigene:24413
Plcb1 GeneProduct ncbigene:24654
Rela GeneProduct ncbigene:309165
Il2 GeneProduct ncbigene:116562
PIK3CA GeneProduct ncbigene:170911
Il2rg GeneProduct ncbigene:140924
Stam2 GeneProduct ncbigene:311030
Nfkb1 GeneProduct ncbigene:81736
Prkcz GeneProduct ncbigene:25522
Il2 GeneProduct ncbigene:116562
Stat5b GeneProduct ncbigene:25126
Map2k2 GeneProduct ncbigene:58960
Nmi GeneProduct ncbigene:311021
Fyn GeneProduct ncbigene:25150
Kras GeneProduct ncbigene:24525
Mapk9 GeneProduct ncbigene:50658
Mapkapk2 GeneProduct ncbigene:289014
Mapk1 GeneProduct ncbigene:116590
Ybx1 GeneProduct ncbigene:500538
Rps6kb1 GeneProduct ncbigene:83840
Pik3cg GeneProduct ncbigene:298947
Il2 GeneProduct ncbigene:116562
Raf1 GeneProduct ncbigene:24703
Crkl GeneProduct ncbigene:287942
Mapk1 GeneProduct ncbigene:116590
Sos1 GeneProduct ncbigene:313845
Nfkb1 GeneProduct ncbigene:81736
Mapk14 GeneProduct ncbigene:81649
Hsp90aa1 GeneProduct ncbigene:299331
Mapk3 GeneProduct ncbigene:50689
Irs1 GeneProduct ncbigene:25467
Foxo3 GeneProduct ncbigene:294515
Rela GeneProduct ncbigene:309165
Mapk3 GeneProduct ncbigene:50689
Ptpn6 GeneProduct ncbigene:116689
Shc1 GeneProduct ncbigene:85385
Irs2 GeneProduct ncbigene:29376

References

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. NetPath: a public resource of curated signal transduction pathways. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia