Signal transduction of S1P receptor (WP57)

This is a representation of figure 2 from T. Hla, et al. 2001, Science, 294, pg. 1877. Sphingosine-1-phosphate (S1P) is a signaling sphingolipid, also known as lysosphingolipid. It is also referred to as a bioactive lipid mediator. Sphingolipids at large form a class of lipids characterized by a particular aliphatic aminoalcohol, which is sphingosine.
last edited


S.Doniger, MaintBot, Ddigles, Khanspers, and Eweitz

Cited In


Mus musculus



Pathway Ontology: sphingosine 1-phosphate signaling pathway


Label Type Compact Identifier
Mapk3 GeneProduct ncbigene:26417
Pik3c2g GeneProduct ncbigene:18705
Edg3 GeneProduct ncbigene:13610
Mapk1 GeneProduct ncbigene:26413
Racgap1 GeneProduct ncbigene:26934
Edg1 GeneProduct ncbigene:13609
Sphk1 GeneProduct ncbigene:20698
Gnai1 GeneProduct ncbigene:14677
Mapk7 GeneProduct ncbigene:23939
Plcb3 GeneProduct ncbigene:18797
Akt2 GeneProduct ncbigene:11652
Asah2 GeneProduct ncbigene:54447
Smpd2 GeneProduct ncbigene:20598
Gnai2 GeneProduct ncbigene:14678
Edg8 GeneProduct ncbigene:94226
Mapk12 GeneProduct ncbigene:29857
Akt3 GeneProduct ncbigene:23797
Akt1 GeneProduct ncbigene:11651
Mapk6 GeneProduct ncbigene:50772
Sphk2 GeneProduct ncbigene:56632
Gnai3 GeneProduct ncbigene:14679
Edg5 GeneProduct ncbigene:14739