Hedgehog signaling pathway (WP574)

The Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, prevents inhibition of a 7 transmembrane receptor called Smoothened. This leads to activation of GLI family of transcription factors (GLI1-3). Signaling through the Hedgehog pathway is essential for development of many tissues and organs. This pathway is highly conserved among metazoans. Aberrant activation of this pathway has been associated with a number of human malignancies including carcinoma of lung, esophagus, pancreas and prostate. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_10
last edited

Authors

A.Pandey, MaintBot, AlexanderPico, Christine Chichester, Mkutmon, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: Hedgehog signaling pathway

Participants

Label Type Compact Identifier
Gli1 GeneProduct ncbigene:140589
Sufu GeneProduct ncbigene:361769
Dyrk1a GeneProduct ncbigene:25255
Ihh GeneProduct ncbigene:84399
GAS1 GeneProduct ncbigene:83818
Ccnb1 GeneProduct ncbigene:25203
PTCH2 GeneProduct ncbigene:366452
Dhh GeneProduct ncbigene:84380
Crebbp GeneProduct ncbigene:54244
Ihh GeneProduct ncbigene:84399
Cdc2 GeneProduct ncbigene:54237
PTCH2 GeneProduct ncbigene:366452
GLI3 GeneProduct ncbigene:140588
Cdc2 GeneProduct ncbigene:54237
Hhip GeneProduct ncbigene:291936
Sufu GeneProduct ncbigene:361769
Ptch1 GeneProduct ncbigene:89830
GLI3 GeneProduct ncbigene:140588
Shh GeneProduct ncbigene:29499
Igf2 GeneProduct ncbigene:24483
Ski GeneProduct ensembl:ENSRNOG00000055340
Dhh GeneProduct ncbigene:84380
Dhh GeneProduct ncbigene:84380
Rab23 GeneProduct ncbigene:367242
Gli1 GeneProduct ncbigene:140589
Hhip GeneProduct ncbigene:291936
Stk36 GeneProduct ncbigene:301516
Smo GeneProduct ncbigene:25273
Shh GeneProduct ncbigene:29499
Ptch1 GeneProduct ncbigene:89830
Sufu GeneProduct ncbigene:361769
Sap18 GeneProduct ncbigene:290284
Shh GeneProduct ncbigene:29499
Gli2 GeneProduct ncbigene:304729
Ccnb1 GeneProduct ncbigene:25203
Hhip GeneProduct ncbigene:291936
Ihh GeneProduct ncbigene:84399
PTCH2 GeneProduct ncbigene:366452
Gli2 GeneProduct ncbigene:304729
Ptch1 GeneProduct ncbigene:89830
Sin3a GeneProduct ncbigene:363067
Shh GeneProduct ncbigene:29499
Ptch1 GeneProduct ncbigene:89830
Smo GeneProduct ncbigene:25273
Rab23 GeneProduct ncbigene:367242

References

  1. Mohler J. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Genetics. 1988 Dec;120(4):1061–72. PubMed Europe PMC Scholia
  2. Lum L, Beachy PA. The Hedgehog response network: sensors, switches, and routers. Science. 2004 Jun 18;304(5678):1755–9. PubMed Europe PMC Scholia