EPO receptor signaling (WP581)

The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP581 CPTAC Assay Portal]
last edited

Authors

Thomas, MaintBot, Christine Chichester, Mkutmon, Khanspers, and Eweitz

Cited In

Organism

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology: erythropoietin signaling pathway oxidative phosphorylation pathway

Participants

Label Type Compact Identifier
EPOR GeneProduct ncbigene:2057
JAK2 GeneProduct ncbigene:3717
SRC GeneProduct ncbigene:6714
EPOR GeneProduct ncbigene:2057
PI3K GeneProduct ncbigene:5294
GRB2 GeneProduct ncbigene:2885
EPO GeneProduct ncbigene:2056
SHC1 GeneProduct ncbigene:6464
PDK1 GeneProduct ncbigene:5163
STAT1 GeneProduct ncbigene:6772
ERK1 GeneProduct ncbigene:5595
MEK1 GeneProduct ncbigene:5604
MEK2 GeneProduct ncbigene:5605
EPO GeneProduct ncbigene:2056
PKB GeneProduct ncbigene:207
ERK2 GeneProduct ncbigene:5594
SOCS1 GeneProduct ncbigene:8651
STAT5B GeneProduct ncbigene:6777
CISH GeneProduct ncbigene:1154
STAT5A GeneProduct ncbigene:6776
STAT3 GeneProduct ncbigene:6774
STAT3 GeneProduct ncbigene:6774
STAT1 GeneProduct ncbigene:6772
CD45 GeneProduct ncbigene:5788
PTP GeneProduct ncbigene:10076
GRB2 GeneProduct ncbigene:2885
RAF1 GeneProduct ncbigene:5894
SOS1 GeneProduct ncbigene:6654
IRS2 GeneProduct ncbigene:8660
JAK2 GeneProduct ncbigene:3717
IRS1 GeneProduct ncbigene:3667
RASA1 GeneProduct ncbigene:5921
RAF1 GeneProduct ncbigene:5894
SOS1 GeneProduct ncbigene:6654
RAS GeneProduct ncbigene:5921

References

  1. Zhu Y, D’Andrea AD. The molecular physiology of erythropoietin and the erythropoietin receptor. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
  2. Lacombe C, Mayeux P. The molecular biology of erythropoietin. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia