Interferon type I signaling pathways (WP585)

The type I IFNs (IFNα family, IFNβ, IFNω, IFNε and IFNκ) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other accessory proteins. The pathway above (WP585) describes the Type I Interferon signaling pathways and shows both classical IFN signaling via the JAK-STAT pathway (dark lines) and other non-canonical IFN signaling pathways. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited

Authors, MaintBot, Jildau, Khanspers, MartijnVanIersel, Egonw, and AlexanderPico

Cited In


Homo sapiens




Pathway Ontology: Jak-Stat signaling pathway immune response pathway


Label Type Compact Identifier
GAB2 Protein ncbigene:9846
CRK GeneProduct ncbigene:1398
CBL Protein ncbigene:867
RAPGEF1 Protein ncbigene:2889
RPS6KB1 Protein ncbigene:6198
GTP Metabolite chebi:15996
PTPN6 GeneProduct ncbigene:5777
IFNAR2b Protein ncbigene:3455
JAK1 GeneProduct ncbigene:3716
MAPKAP1 Protein ncbigene:79109
CRKL Protein ncbigene:1399
EIF4E Protein ncbigene:1977
PIAS1 GeneProduct ncbigene:8554
EIF4EBP1 Protein ncbigene:1978
RPTOR Protein ncbigene:57521
PDCD4 Protein ncbigene:27250
STAT3 Protein ncbigene:6774
IRS1 Protein ncbigene:3667
SOCS1 Protein ncbigene:8651
SOCS3 Protein ncbigene:9021
FYN GeneProduct ncbigene:2534
IFNAR1 Protein ncbigene:3454
STAT1 Protein ncbigene:6772
STAT2 Protein ncbigene:6773
EIF4B Protein ncbigene:1975
PIK3CD Protein ncbigene:5293
Rac1 Protein ncbigene:5879
PTPN11 GeneProduct ncbigene:5781
MAP2K3 Protein ncbigene:5606
STAT4 Protein ncbigene:6775
Zap70 GeneProduct ncbigene:7535
GDP Metabolite chebi:17552
CrkL Protein ncbigene:1399
PTPRC GeneProduct ncbigene:5788
IRF9 Protein ncbigene:10379
PIAS3 GeneProduct ncbigene:10401
RPS6KA4 Protein ncbigene:8986
STAT4 Protein ncbigene:6775
TYK2 Protein ncbigene:7297
FRAP1 Protein ncbigene:2475
MLST8 Protein ncbigene:64223
EIF4A1 Protein ncbigene:1973
Lck GeneProduct ncbigene:3932
REL Protein ncbigene:5966
CREB1 Protein ncbigene:1385
STAT5 Protein ncbigene:6776
PRMT1 Protein ncbigene:3276
MAP2K6 Protein ncbigene:5608
STAT2 Protein ncbigene:6773
MTOR Protein ncbigene:2475
RAP1A Protein ncbigene:5906
IRS2 Protein ncbigene:8660
RPS6KA5 Protein ncbigene:9252
PIK3R1 Protein ncbigene:5295
VAV1 Protein ncbigene:7409
RPS6 Protein ncbigene:6194
MAP3K1 Protein ncbigene:4214
GNB2L1 Protein ncbigene:10399
MAPK14 Protein ncbigene:1432
IFNAR2a Protein ncbigene:3455
STAT1 Protein ncbigene:6772
STAT1 Protein ncbigene:6772
IFNAR2c Protein ncbigene:3455
STAT3 Protein ncbigene:6774
Rac1 Protein ncbigene:5879
PIK3R2 Protein ncbigene:5296
STAT1 Protein ncbigene:6772
STAT3 Protein ncbigene:6774
STAT3 Protein ncbigene:6774
STAT1 Protein ncbigene:6772
STAT2 Protein ncbigene:6773


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