Type II interferon signaling (WP619)

Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP619 CPTAC Assay Portal]
last edited

Authors

Thomas, MaintBot, Khanspers, Ddigles, Mkutmon, and Egonw

Cited In

Organism

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology: Jak-Stat signaling pathway type II interferon signaling pathway

Participants

Label Type Compact Identifier
STAT2 [P] GeneProduct ncbigene:6773
IFNG GeneProduct ncbigene:3458
STAT1 GeneProduct ncbigene:6772
SPI1 GeneProduct ncbigene:6688
OAS1 GeneProduct ncbigene:4938
IRF9 GeneProduct ncbigene:10379
IRF8 [P] GeneProduct ncbigene:3394
IRF9 GeneProduct ncbigene:10379
IFNG GeneProduct ncbigene:3458
JAK2 GeneProduct ncbigene:3717
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
IFNG GeneProduct ncbigene:3458
IFNG GeneProduct ncbigene:3458
STAT1 GeneProduct ncbigene:6772
JAK1 GeneProduct ncbigene:3716
STAT1 GeneProduct ncbigene:6772
CXCL9 GeneProduct ncbigene:4283
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
STAT2 GeneProduct ncbigene:6773
IFNA GeneProduct ncbigene:3440
SOCS1 GeneProduct ncbigene:8651
CYBB GeneProduct ncbigene:1536
(ISGF3) GeneProduct ncbigene:10379
PTPN11 GeneProduct ncbigene:5781
ICAM1 GeneProduct ncbigene:3383
IRF2 GeneProduct ncbigene:3660
IFNGR2 GeneProduct ncbigene:3460
GBP1 GeneProduct ncbigene:2633
TAP1 GeneProduct ncbigene:6890
IRF8 GeneProduct ncbigene:3394
IFNGR2 GeneProduct ncbigene:3460
(ISGF3) GeneProduct ncbigene:10379
IFNGR1 GeneProduct ncbigene:3459
STAT1 GeneProduct ncbigene:6772
JAK1 GeneProduct ncbigene:3716
HIST2H4 GeneProduct ncbigene:8370
IFNGR1 GeneProduct ncbigene:3459
JAK1 GeneProduct ncbigene:3716
IFNB1 GeneProduct ncbigene:3456
STAT1 GeneProduct ncbigene:6772
JAK2 GeneProduct ncbigene:3717
IL1B GeneProduct ncbigene:3553
JAK1 GeneProduct ncbigene:3716
JAK2 GeneProduct ncbigene:3717
IFNGR2 GeneProduct ncbigene:3460
STAT1 GeneProduct ncbigene:6772
EIF2AK2 GeneProduct ncbigene:5610
STAT2 GeneProduct ncbigene:6773
G1P2 GeneProduct ncbigene:9636
STAT1 GeneProduct ncbigene:6772
NOS2A GeneProduct ncbigene:4843
STAT1 [P] GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
IFNGR1 GeneProduct ncbigene:3459
IFNG GeneProduct ncbigene:3458
STAT1 GeneProduct ncbigene:6772
IFNGR1 GeneProduct ncbigene:3459
G1P3 GeneProduct ncbigene:2537
IRF1 GeneProduct ncbigene:3659
CXCL10 GeneProduct ncbigene:3627
PSMB9 GeneProduct ncbigene:5698
SOCS3 GeneProduct ncbigene:9021
IRF9 GeneProduct ncbigene:10379
STAT2 GeneProduct ncbigene:6773
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
PRKCD GeneProduct ncbigene:5580
STAT1 GeneProduct ncbigene:6772
IRF4 GeneProduct ncbigene:3662
HLA-B GeneProduct ncbigene:3106
IFNGR2 GeneProduct ncbigene:3460
IFIT2 GeneProduct ncbigene:3433
CIITA GeneProduct ncbigene:4261
JAK2 GeneProduct ncbigene:3717
PTP GeneProduct ncbigene:5967
IRF9 GeneProduct ncbigene:10379
IRF9 GeneProduct ncbigene:10379

References

  1. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, et al. A logic-based diagram of signalling pathways central to macrophage activation. BMC Syst Biol. 2008 Apr 23;2:36. PubMed Europe PMC Scholia