Cholesterol metabolism (WP632)

Cholesterol is essential for life - it's a required for the regulation of membrane fluidity. Cholesterol also serves as a precursor for many other biochemical pathways. Cholesterol is synthesized throughout the body but mainly in liver, intestines, adrenal glands and reproductive organs. Synthesis starts with the combination of Acetyl-CoA and Acetoacetyl-CoA. An important intemediary in the synthesis of cholesterol is mevalonate. Synthesis of cholesterol is regulated by a homeostatic mechanism.
last edited

Authors

Susan, 442798, I450472, Khanspers, MaintBot, Mkutmon, Christine Chichester, and Egonw

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: cholesterol metabolic pathway arterial occlusive disease pathway

Participants

Label Type Compact Identifier
Hmgcs1 GeneProduct ncbigene:29637
Soat1 GeneProduct ensembl:ENSRNOG00000004111
Scarb1 GeneProduct ensembl:ENSRNOG00000000981
(S)-2,3-Epoxysqualene Metabolite hmdb:HMDB0001188
Fdft1 GeneProduct ensembl:ENSRNOG00000021314
Isopentenyl pyrophosphate Metabolite hmdb:HMDB0001347
Lathosterol Metabolite hmdb:HMDB0001170
Hmgcr GeneProduct ncbigene:25675
Dimethylallylpyrophosphate Metabolite hmdb:HMDB0001120
Mevalonate Metabolite hmdb:HMDB0000227
Apoe GeneProduct ensembl:ENSRNOG00000018454
HDL Metabolite None
Squalene Metabolite hmdb:HMDB0000256
MVK GeneProduct ncbigene:81727
LDL Metabolite None
Dhcr7 GeneProduct ensembl:ENSRNOG00000020776
Lanosterin Metabolite hmdb:HMDB0001251
IDL Metabolite None
Srebf1 GeneProduct ensembl:ENSRNOG00000003463
Apoc2 GeneProduct ensembl:ENSRNOG00000018402
Lss GeneProduct ensembl:ENSRNOG00000054549
Acetoacetyl-CoA Metabolite hmdb:HMDB0001484
Mevalonate Pyrophosphat Metabolite hmdb:HMDB0001981
Fdps GeneProduct ncbigene:83791
Sqle GeneProduct ensembl:ENSRNOG00000009550
Ldlr GeneProduct ensembl:ENSRNOG00000009946
Cholesterol Metabolite hmdb:HMDB0000067
Lpl GeneProduct ensembl:ENSRNOG00000012181
Lipc GeneProduct ensembl:ENSRNOG00000060338
Apoc1 GeneProduct ensembl:ENSRNOG00000018426
Geranyl pyrophosphate Metabolite hmdb:HMDB0001285
Dehydrocholesterol Metabolite hmdb:HMDB0000032
HMG-CoA Metabolite hmdb:HMDB0001375
Cholesterol ester Metabolite chebi:17002
Cholesterol Metabolite hmdb:HMDB0000067
Fatty Acid CoA Metabolite None
VLDL Metabolite None
Acetyl-CoA Metabolite hmdb:HMDB0001206
Mvd GeneProduct ensembl:ENSRNOG00000013376
Nsdhl GeneProduct ensembl:ENSRNOG00000057814
Idi1 GeneProduct ensembl:ENSRNOG00000016690
Sc4mol GeneProduct ensembl:ENSRNOG00000032297
Lrp1 GeneProduct ncbigene:299858
Farnesyl pyrophosphate Metabolite hmdb:HMDB0000961
Sc5d GeneProduct ensembl:ENSRNOG00000008305

References

  1. Gadbut AP, Wu L, Tang D, Papageorge A, Watson JA, Galper JB. Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins. EMBO J. 1997 Dec 15;16(24):7250–60. PubMed Europe PMC Scholia
  2. Wassmann S, Nickenig G. Improvement of Endothelial Function by HMG-CoA Reductase Inhibitors. Drug News Perspect. 2002 Mar;15(2):85–92. PubMed Europe PMC Scholia