p53 signal pathway (WP656)

We've used the following pathway as a reference: http://www.genome.jp/dbget-bin/show_pathway?rno04115+58918
last edited


Emmaverver, Khanspers, Thomas, Jinggao, MaintBot, Ddigles, and Mkutmon

Cited In


Rattus norvegicus



Pathway Ontology: p53-independent G1/S DNA damage checkpoint pathway


Label Type Compact Identifier
Cell cycle arrest Pathway None
Apoptosis Pathway wikipathways:WP1290
Dexamethazone Metabolite hmdb:HMDB0015364
p21 GeneProduct ncbigene:24525
Casp3 GeneProduct ensembl:ENSRNOG00000010475
Scotin GeneProduct ensembl:ENSRNOG00000020667
Ei24 GeneProduct ensembl:ENSRNOG00000030391
Bax GeneProduct ensembl:ENSRNOG00000020876
Cyclin D GeneProduct uniprot:P48961
Mdm2 GeneProduct ensembl:ENSRNOG00000006304
Gtse1 GeneProduct ensembl:ENSRNOG00000016148
Casp9 GeneProduct ensembl:ENSRNOG00000012944
Bid GeneProduct ensembl:ENSRNOG00000012439
Cdk4 GeneProduct ensembl:ENSRNOG00000025602
Sfn GeneProduct ensembl:ENSRNOG00000033153
Casp8 GeneProduct ensembl:ENSRNOG00000012331
Igf1 GeneProduct ensembl:ENSRNOG00000004517
Cdk2 GeneProduct ensembl:ENSRNOG00000006469
Zmat3 GeneProduct ensembl:ENSRNOG00000010119
Igfbp3 GeneProduct ensembl:ENSRNOG00000061910
Reprimo GeneProduct ensembl:ENSRNOG00000005109
Apaf 1 GeneProduct ensembl:ENSRNOG00000008022
Tp53 GeneProduct ensembl:ENSRNOG00000010756
Cdc2 GeneProduct ensembl:ENSRNOG00000000632
Parp1 GeneProduct ensembl:ENSRNOG00000003084
Cyclin B3 GeneProduct ensembl:ENSRNOG00000002951
Noxa GeneProduct ensembl:ENSRNOG00000018770
Gadd45 GeneProduct ensembl:ENSRNOG00000013090
Tp53 GeneProduct ensembl:ENSRNOG00000010756
Puma GeneProduct uniprot:Q80ZG6
Phenobarbital Metabolite hmdb:HMDB0015305
Perp GeneProduct ensembl:ENSRNOG00000011994
Cytochrome C1 Metabolite chebi:4067
Fas GeneProduct ensembl:ENSRNOG00000019142
Siah GeneProduct ensembl:ENSRNOG00000015143
Cyclin E GeneProduct ensembl:ENSRNOG00000014786


  1. Malanga M, Pleschke JM, Kleczkowska HE, Althaus FR. Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions. J Biol Chem. 1998 May 8;273(19):11839–43. PubMed Europe PMC Scholia
  2. Simbulan-Rosenthal CM, Rosenthal DS, Ding R, Bhatia K, Smulson ME. Prolongation of the p53 response to DNA strand breaks in cells depleted of PARP by antisense RNA expression. Biochem Biophys Res Commun. 1998 Dec 30;253(3):864–8. PubMed Europe PMC Scholia
  3. Nelson DM, Bhaskaran V, Foster WR, Lehman-McKeeman LD. p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile. Toxicol Sci. 2006 Dec;94(2):272–80. PubMed Europe PMC Scholia