Leptin and adiponectin (WP683)

Proposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in [http://www.ncbi.nlm.nih.gov/pubmed/16497175 Dyck et al.].
last edited

Authors

Thomas, MaintBot, and Egonw

Cited In

Organism

Mus musculus

Communities

Annotations

Disease Ontology: glucose metabolism disease

Pathway Ontology: leptin system pathway adiponectin signaling pathway

Participants

Label Type Compact Identifier
Adipor1 GeneProduct ncbigene:72674
Fatty acid Metabolite chebi:35366
Prkaa1 GeneProduct ncbigene:105787
Prkab1 GeneProduct ncbigene:19079
Leptin GeneProduct ncbigene:16846
Fatty acid Metabolite chebi:35366
Adipor2 GeneProduct ncbigene:68465
Acc1 GeneProduct ncbigene:107476
Acetyl-CoA Metabolite chebi:15351
Prkag1 GeneProduct ncbigene:19082
Lepr GeneProduct ncbigene:16847
Cpt1 GeneProduct ncbigene:12894
Adiponectin GeneProduct ncbigene:11450
Malonyl-CoA Metabolite chebi:15531

References

  1. Dyck DJ, Heigenhauser GJF, Bruce CR. The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity. Acta Physiol (Oxf). 2006 Jan;186(1):5–16. PubMed Europe PMC Scholia