Metapathway biotransformation Phase I and II (WP702)

Biotransformation is the chemical modification (or modifications) made by an organism on a chemical compound. If this modification ends in mineral compounds like CO2, NH4+, or H2O, the biotransformation is called mineralisation. Biotransformation means chemical alteration of chemicals such as nutrients, amino acids, toxins, and drugs in the body. It is also needed to render non-polar compounds polar so that they are not reabsorbed in renal tubules and are excreted. Biotransformation of xenobiotics can dominate toxicokinetics and the metabolites may reach higher concentrations in organisms than their parent compounds. [https://en.wikipedia.org/wiki/Biotransformation] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP702 CPTAC Assay Portal]
last edited

Authors

Pieter Giesbertz, Khanspers, MaintBot, MartijnVanIersel, Ddigles, DeSl, Fehrhart, AlexanderPico, and Egonw

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: phase I biotransformation pathway cellular detoxification pathway phase II biotransformation pathway phase I biotransformation pathway via cytochrome P450

Participants

Label Type Compact Identifier
GSTA5 GeneProduct ensembl:ENSG00000182793
Sulfotransferase GeneProduct None
CYP4B1 GeneProduct ensembl:ENSG00000142973
NDST4 GeneProduct ensembl:ENSG00000138653
GSTA4 GeneProduct ensembl:ENSG00000170899
AKR7A2 GeneProduct ensembl:ENSG00000053371
NAT12 GeneProduct ensembl:ENSG00000139977
NAT1 GeneProduct ensembl:ENSG00000171428
Flavin monooxygenase GeneProduct None
SULT1C2 GeneProduct ensembl:ENSG00000198075
UGT1A5 GeneProduct ncbigene:54579
NAT2 GeneProduct ensembl:ENSG00000156006
Substrate-SH Metabolite None
UGT1A4 GeneProduct ncbigene:54657
CYP39A1 GeneProduct ensembl:ENSG00000146233
CYP27A1 GeneProduct ensembl:ENSG00000135929
CYP2D6 GeneProduct ensembl:ENSG00000100197
NDST2 GeneProduct ensembl:ENSG00000166507
CYP2U1 GeneProduct ensembl:ENSG00000155016
CYP450 GeneProduct pfam:PF00067
FMO5 GeneProduct ensembl:ENSG00000131781
NDST3 GeneProduct ensembl:ENSG00000164100
HS6ST1 GeneProduct ensembl:ENSG00000136720
GSTT2 GeneProduct ensembl:ENSG00000099984
UGT1A7 GeneProduct ncbigene:54577
CYP4F3 GeneProduct ensembl:ENSG00000186529
AKR1C2 GeneProduct ensembl:ENSG00000151632
CYP4X1 GeneProduct ensembl:ENSG00000186377
HS3ST1 GeneProduct ensembl:ENSG00000002587
MGST2 GeneProduct ensembl:ENSG00000085871
HS3ST3A1 GeneProduct ensembl:ENSG00000153976
Amino acid acyltransferase GeneProduct None
CYP2A7 GeneProduct ensembl:ENSG00000198077
CYP4F22 GeneProduct ensembl:ENSG00000171954
GPX1 GeneProduct ensembl:ENSG00000197582
Substrate-NH2 Metabolite None
N-acetyltransferase GeneProduct None
CHST7 GeneProduct ensembl:ENSG00000147119
TPMT GeneProduct ensembl:ENSG00000137364
GLYAT GeneProduct ensembl:ENSG00000149124
HNMT GeneProduct ensembl:ENSG00000150540
BAAT GeneProduct ensembl:ENSG00000136881
FMO3 GeneProduct ensembl:ENSG00000007933
CYP2B6 GeneProduct ensembl:ENSG00000197408
CYP2C19 GeneProduct ensembl:ENSG00000165841
CHST1 GeneProduct ensembl:ENSG00000175264
GSTA1 GeneProduct ensembl:ENSG00000243955
CYP24A1 GeneProduct ensembl:ENSG00000019186
CHST3 GeneProduct ensembl:ENSG00000122863
UGT1A10 GeneProduct ncbigene:54575
CYP4F12 GeneProduct ensembl:ENSG00000186204
UGT2B4 GeneProduct ensembl:ENSG00000156096
SULT1B1 GeneProduct ensembl:ENSG00000173597
UGT1A9 GeneProduct ncbigene:54600
CYP27C1 GeneProduct ensembl:ENSG00000186684
CYP2A6 GeneProduct ensembl:ENSG00000255974
SULT1C4 GeneProduct ncbigene:27233
CYP46A1 GeneProduct ensembl:ENSG00000036530
CYP2C9 GeneProduct ensembl:ENSG00000138109
Substrate=O Metabolite None
CYP4V2 GeneProduct ensembl:ENSG00000145476
NAT6 GeneProduct ensembl:ENSG00000243477
GSTM4 GeneProduct ensembl:ENSG00000168765
GPX2 GeneProduct ensembl:ENSG00000176153
CYP11B1 GeneProduct ensembl:ENSG00000160882
Substrate-Aa Metabolite None
CYP2C18 GeneProduct ensembl:ENSG00000108242
CYP4F11 GeneProduct ensembl:ENSG00000171903
GLYATL1 GeneProduct ensembl:ENSG00000166840
Substrate-CH3 Metabolite None
UGT1A1 GeneProduct ncbigene:54658
CYP1A2 GeneProduct ensembl:ENSG00000140505
AKR1B1 GeneProduct ensembl:ENSG00000085662
HS3ST2 GeneProduct ensembl:ENSG00000122254
NAT14 GeneProduct ensembl:ENSG00000090971
GPX3 GeneProduct ensembl:ENSG00000211445
CYP1B1 GeneProduct ensembl:ENSG00000138061
GLYATL2 GeneProduct ensembl:ENSG00000156689
GSTO1 GeneProduct ensembl:ENSG00000148834
CYP20A1 GeneProduct ensembl:ENSG00000119004
CYP2S1 GeneProduct ensembl:ENSG00000167600
SULT1E1 GeneProduct ensembl:ENSG00000109193
CYP19A1 GeneProduct ensembl:ENSG00000137869
CYP21A2 GeneProduct ncbigene:1589
AKR7A3 GeneProduct ensembl:ENSG00000162482
CYP26C1 GeneProduct ensembl:ENSG00000187553
SULT2A1 GeneProduct ensembl:ENSG00000105398
HS6ST2 GeneProduct ensembl:ENSG00000171004
CYP27B1 GeneProduct ensembl:ENSG00000111012
CYP26B1 GeneProduct ensembl:ENSG00000003137
GSTT1 GeneProduct ensembl:ENSG00000277656
AKR1A1 GeneProduct ensembl:ENSG00000117448
FMO1 GeneProduct ensembl:ENSG00000010932
UGT2B7 GeneProduct ensembl:ENSG00000171234
NAT5 GeneProduct ensembl:ENSG00000173418
UGT2A2 GeneProduct ncbigene:574537
INMT GeneProduct ensembl:ENSG00000241644
NNMT GeneProduct ensembl:ENSG00000166741
GSTM2 GeneProduct ensembl:ENSG00000213366
AKR1C3 GeneProduct ensembl:ENSG00000196139
Aldo-keto reductase GeneProduct None
Methyltransferase GeneProduct None
CYP2W1 GeneProduct ensembl:ENSG00000073067
NAT10 GeneProduct ensembl:ENSG00000135372
CHST11 GeneProduct ensembl:ENSG00000171310
CHST9 GeneProduct ncbigene:83539
SULT1C3 GeneProduct ensembl:ENSG00000196228
GAL3ST4 GeneProduct ensembl:ENSG00000197093
CYP3A7 GeneProduct ensembl:ENSG00000160870
UGT2B15 GeneProduct ensembl:ENSG00000196620
UGT2B11 GeneProduct ensembl:ENSG00000213759
CYP7A1 GeneProduct ensembl:ENSG00000167910
GSTZ1 GeneProduct ensembl:ENSG00000100577
Substrate-O-R Metabolite None
CYP4F2 GeneProduct ensembl:ENSG00000186115
CHST2 GeneProduct ensembl:ENSG00000175040
CYP2F1 GeneProduct ensembl:ENSG00000197446
GAL3ST1 GeneProduct ensembl:ENSG00000128242
HS3ST5 GeneProduct ensembl:ENSG00000249853
GSTK1 GeneProduct ensembl:ENSG00000197448
GAL3ST3 GeneProduct ensembl:ENSG00000175229
HS2ST1 GeneProduct ensembl:ENSG00000153936
CYP8B1 GeneProduct ensembl:ENSG00000180432
CYP1A1 GeneProduct ensembl:ENSG00000140465
Glucuronosyltransferase GeneProduct None
GSR GeneProduct ensembl:ENSG00000104687
Substrate-Ac Metabolite None
SULT4A1 GeneProduct ensembl:ENSG00000130540
Substrate-OH Metabolite None
HS6ST3 GeneProduct ensembl:ENSG00000185352
CYP11B2 GeneProduct ensembl:ENSG00000179142
GSTM5 GeneProduct ensembl:ENSG00000134201
CYP4Z1 GeneProduct ensembl:ENSG00000186160
Substrate-Gl Metabolite None
AKR1C4 GeneProduct ensembl:ENSG00000198610
UGT2A1 GeneProduct ensembl:ENSG00000173610
NDST1 GeneProduct ensembl:ENSG00000070614
AKR1C1 GeneProduct ensembl:ENSG00000187134
KCNAB1 GeneProduct ensembl:ENSG00000169282
GSTCD GeneProduct ensembl:ENSG00000138780
CHST13 GeneProduct ensembl:ENSG00000180767
CYP7B1 GeneProduct ensembl:ENSG00000172817
CYP11A1 GeneProduct ensembl:ENSG00000140459
CYP2C8 GeneProduct ensembl:ENSG00000138115
UGT2A3 GeneProduct ensembl:ENSG00000135220
CHST10 GeneProduct ensembl:ENSG00000115526
SULT1C1 GeneProduct ensembl:ENSG00000198203
EPHX1 GeneProduct ensembl:ENSG00000143819
NAT9 GeneProduct ensembl:ENSG00000109065
NAT8L GeneProduct ensembl:ENSG00000185818
SULT1A2 GeneProduct ensembl:ENSG00000197165
NAT13 GeneProduct ensembl:ENSG00000121579
HS3ST4 GeneProduct ensembl:ENSG00000182601
UGT1A6 GeneProduct ncbigene:54578
GPX4 GeneProduct ensembl:ENSG00000167468
CYP2R1 GeneProduct ensembl:ENSG00000186104
HS3ST3B1 GeneProduct ensembl:ENSG00000125430
SULT2B1 GeneProduct ensembl:ENSG00000088002
GSS GeneProduct ensembl:ENSG00000100983
GPX5 GeneProduct ensembl:ENSG00000224586
Substrate-SO3H Metabolite None
Glutathione transferase GeneProduct pfam:PF00043
CYP4F8 GeneProduct ensembl:ENSG00000186526
EPHX2 GeneProduct ensembl:ENSG00000120915
CHST5 GeneProduct ensembl:ENSG00000135702
UGT2B28 GeneProduct ensembl:ENSG00000135226
CYP3A4 GeneProduct ensembl:ENSG00000160868
GSTM1 GeneProduct ensembl:ENSG00000134184
KCNAB3 GeneProduct ensembl:ENSG00000170049
FMO2 GeneProduct ensembl:ENSG00000094963
GSTA3 GeneProduct ensembl:ENSG00000174156
KCNAB2 GeneProduct ensembl:ENSG00000069424
NAT11 GeneProduct ensembl:ENSG00000110583
FMO4 GeneProduct ensembl:ENSG00000076258
CYP26A1 GeneProduct ensembl:ENSG00000095596
SULT1A1 GeneProduct ensembl:ENSG00000196502
CYP2E1 GeneProduct ensembl:ENSG00000130649
CHST14 GeneProduct ncbigene:113189
SULT6B1 GeneProduct ensembl:ENSG00000138068
HS3ST6 GeneProduct ensembl:ENSG00000162040
CYP17A1 GeneProduct ensembl:ENSG00000148795
CHST4 GeneProduct ensembl:ENSG00000140835
MGST1 GeneProduct ensembl:ENSG00000008394
UGT2B17 GeneProduct ensembl:ENSG00000197888
SULT1A4 GeneProduct ensembl:ENSG00000213648
AKR1B10 GeneProduct ensembl:ENSG00000198074
NAT8 GeneProduct ensembl:ENSG00000144035
CYP3A43 GeneProduct ensembl:ENSG00000021461
SULT1A3 GeneProduct ensembl:ENSG00000213599
UGT1A8 GeneProduct ensembl:ENSG00000167165
CYP3A5 GeneProduct ensembl:ENSG00000106258
GSTA2 GeneProduct ensembl:ENSG00000244067
GSTP1 GeneProduct ensembl:ENSG00000084207
COMT GeneProduct ensembl:ENSG00000093010
CHST6 GeneProduct ensembl:ENSG00000183196
Substrate-SG Metabolite None
Xenobiotic substrate Metabolite None
UGT1A3 GeneProduct ncbigene:54659
CYP2J2 GeneProduct ensembl:ENSG00000134716
MGST3 GeneProduct ensembl:ENSG00000143198
AKR1D1 GeneProduct ensembl:ENSG00000122787
GSTO2 GeneProduct ensembl:ENSG00000065621
GSTM3 GeneProduct ensembl:ENSG00000134202
GAL3ST2 GeneProduct ensembl:ENSG00000154252
GSTT2B GeneProduct ensembl:ENSG00000133433
CHST8 GeneProduct ensembl:ENSG00000124302
CYP2A13 GeneProduct ensembl:ENSG00000197838
CYP51A1 GeneProduct ensembl:ENSG00000001630
CHST12 GeneProduct ensembl:ENSG00000136213

References

  1. Oppermann UC, Maser E. Molecular and structural aspects of xenobiotic carbonyl metabolizing enzymes. Role of reductases and dehydrogenases in xenobiotic phase I reactions. Toxicology. 2000 Apr 3;144(1–3):71–81. PubMed Europe PMC Scholia