Sudden infant death syndrome (SIDS) susceptibility pathways (WP706)

In this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an overview of research in this field and recommend new candidates for more focused or genome wide analyses. SIDS is the sudden and unexpected death of an infant (less than 1 year of age), almost always during deep sleep, where no cause of death can be found by autopsy. Factors that mediate SIDS are likely to be both biological and behavioral, such as sleeping position, environment and stress during a critical phase of infant development (http://www.nichd.nih.gov/health/topics/Sudden_Infant_Death_Syndrome.cfm). While no clear diagnostic markers currently exist, several polymorphisms have been identified which are significantly over-represented in distinct SIDS ethnic population. The large majority of these polymorphisms exist in genes associated with neuronal signaling, cardiac contraction and inflammatory response. These and other lines of evidence suggest that SIDS has a strong autonomic nervous system component (PMID:12350301, PMID: 20124538). One of the neuronal nuclei most strongly implicated in SIDS has been the raphe nucleus of the brain stem. In this nuclei there are ultrastructural, cellular and molecular changes associated with SIDS relative to controls (PMID:19342987, PMID: 20124538). This region of the brain is responsible for the large majority of neuronal serotonin produced and is functionally important in the regulation of normal cardiopulmonary activity, sleep and thermoregulation (see associated references). Genes associated with serotonin synthesis and receptivity have some of the strongest genetic association with SIDS. Principle among these genes the serotonin biosynthetic enzyme TPH2, the serotonin transporter SLC6A4 and the serotonin receptor HTR1A. SLC6A4 exhibits decreased expression in the raphe nucleus of the medulla oblongata and polymorphisms specifically associated with SIDS (PMID:19342987). In 75% of infants with SIDS, there is decreased HTR1A expression relative to controls along with an increase in the number of raphe serotonin neurons (PMID:19342987). Over-expression of the mouse orthologue of the HTR1A gene in the juvenile mouse medulla produces an analogous phenotype to SIDS with death due to bradycardia and hypothermia (PMID:18599790). These genes as well as those involved in serotonin synthesis are predicted to be transcriptionally regulated by a common factor, FEV (human orthologue of PET-1). PET-1 knock-out results in up to a 90% loss of serotonin neurons (PMID:12546819), while polymorphisms in FEV are over-represented in African American infants with SIDS. In addition to FEV, other transcription factors implicated in the regulation of these genes (Putative transcriptional regulators (TRs)) and FEV are also listed (see associated references). In addition to serotonin, vasopressin signaling and its regulation by serotonin appear to be important in a common pathway of cardiopulmonary regulation (PMID:2058745). A protein that associates with vasopressin signaling, named pituitary adenylate cyclase-activating polypeptide (ADCYAP1), results in a SIDS like phenotype, characterized by a high increase in spontaneous neonatal death, exacerbated by hypothermia and hypoxia (PMID:14608012), when disrupted in mice. Protein for this gene is widely distributed throughout the central nervous system (CNS), including autonomic control centers (PMID:12389210). ADCYAP1 and HTR1A are both predicted to be transcriptionally regulated by REST promoter binding. Regulation of G-protein coupled signaling pathways is illustrated for these genes, however, it is not clear whether ADCYAP1 acts directly upon raphe serotonin neurons. Another potentially important class of receptors in SIDS is nicotine. Receptors for nicotine are expressed in serotonin neurons of the raphe throughout development (PMID:18986852). Application of nicotine or cigarette smoke is sufficient to inhibit electrical activity of raphe serotonin neurons (PMID:17515803) and chronic nicotine infusion in rats decreases expression of SLC6A4 (PMID:18778441). Furthermore, nicotine exposure reduces both HTR1A and HTR2A immunoreactivity in several nuclei of the brainstem (PMID:17451658). In addition to CNS abnormalities, several studies have identified a critical link between cardiac arrhythmia (long QT syndrome) and SIDS (PMID:18928334). A number of genetic association studies identified functionally modifying mutations in critical cardiac channels in as many as 10% of all SIDS cases (PMID:18928334). These mutations have been predicted to predispose infants for long QT syndrome and sudden death. The highest proportion of SIDS associated mutations (both inherited and sporadic) is found in the sodium channel gene SCN5A. Examination of putative transcriptional regulators for these genes, highlights a diverse set of factors as well as a relatively common one (SP1). Finally, several miscellaneous mutations have been identified in genes associated with inflammatory response and thermoregulation. Infection is considered a significant risk factor for SIDS (PMID:19114412). For inflammatory associated genes, such as TNF alpha, interleukin 10 and complement component 4, many of these mutations are only significant in the presence of infection and SIDS. In addition to these mutations, cerebrospinal fluid levels of IL6 are increased in SIDS cases as well as IL6R levels in the arcuate nucleus of the brain, another major site of serotonin synthesis (PMID:19396608). Genes such as ILR6 and ADCYAP1 are also associated with autoimmune disorders, thus SIDS may also be associated with autoinflammation of autonomic centers in the brain. Regulation of thermogenesis by brown adipose tissue has been proposed be an important component of SIDS, given that SIDS incidence is highest in the winter time and that animal models of SIDS demonstrate variation in body temperature. Interestingly, activation of raphe HTR1A decreases both shivering and peripheral vasoconstriction in piglets (18094064). Although a putative significant polymorphism was identified in the thermoregulator gene HSP60, this only occurred in one SIDS case. It is important to note that in the large majority of all these studies, sleeping position and smoking were among the most significant risk factors for SIDS. In loving memory of Milo Salomonis (http://www.milosalomonis.org). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP706 CPTAC Assay Portal].
last edited

Authors

Nsalomonis, AlexanderPico, MaintBot, Khanspers, Ddigles, Egonw, LarsEijssen, MirellaKalafati, Fehrhart, Finterly, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Diseases

Annotations

Cell Type Ontology: raphe nuclei neuron cardiac muscle cell

Pathway Ontology: serotonin signaling pathway

Disease Ontology: sudden infant death syndrome

Participants

Label Type Compact Identifier
SCN5A GeneProduct ncbigene:6331
TACR1 GeneProduct ensembl:ENSG00000115353
ADCYAP1 GeneProduct ncbigene:116
ALDOA GeneProduct ensembl:ENSG00000149925
IL10 GeneProduct ncbigene:3586
TPH1 GeneProduct ncbigene:7166
5-HT Metabolite hmdb:HMDB0000259
CREB1 GeneProduct ensembl:ENSG00000118260
MAZ GeneProduct ensembl:ENSG00000103495
SSTR2 GeneProduct ensembl:ENSG00000180616
MAOA GeneProduct ncbigene:4128
NR3C1 GeneProduct ensembl:ENSG00000113580
SP1 GeneProduct ncbigene:6667
HES1 GeneProduct ncbigene:3280
ACADM GeneProduct ncbigene:34
C4B GeneProduct ncbigene:721
REST GeneProduct ncbigene:5978
HTR1A GeneProduct ncbigene:3350
CC2D1A GeneProduct ncbigene:54862
NFKB1 GeneProduct ensembl:ENSG00000109320
CREB1 GeneProduct ensembl:ENSG00000118260
TPH1 GeneProduct ncbigene:7166
CTCF GeneProduct ncbigene:10664
NKX3-1 GeneProduct ncbigene:4824
HADHA GeneProduct ncbigene:3030
RYR2 GeneProduct ncbigene:6262
CHRNB4 GeneProduct ncbigene:1143
TNF GeneProduct ncbigene:7124
EP300 GeneProduct ncbigene:2033
MEF2C GeneProduct ensembl:ENSG00000081189
REST GeneProduct ncbigene:5978
NGF GeneProduct ensembl:ENSG00000134259
MIR16-1 GeneProduct ncbigene:406950
PLP1 GeneProduct ensembl:ENSG00000123560
C4A GeneProduct ncbigene:720
MIR13A GeneProduct ensembl:ENSG00000208009
RUNX3 GeneProduct ensembl:ENSG00000020633
NEUROD1 GeneProduct ensembl:ENSG00000162992
HIF1A GeneProduct ensembl:ENSG00000100644
DLX2 GeneProduct ensembl:ENSG00000115844
JUN GeneProduct ensembl:ENSG00000177606
GATA2 GeneProduct ncbigene:2624
MIR210 GeneProduct ensembl:ENSG00000199038
CREBBP GeneProduct ensembl:ENSG00000005339
KCNH2 GeneProduct ncbigene:3757
DDC GeneProduct ncbigene:1644
SP3 GeneProduct ensembl:ENSG00000172845
CAV3 GeneProduct ncbigene:859
IL8 GeneProduct ncbigene:3576
CAV3 GeneProduct ncbigene:859
AVP GeneProduct ncbigene:551
ADCYAP1R1 GeneProduct ncbigene:117
PPARGC1A GeneProduct ncbigene:10891
THRB GeneProduct ensembl:ENSG00000151090
PPARGC1B GeneProduct ncbigene:133522
REST GeneProduct ensembl:ENSG00000084093
LMX1B GeneProduct ncbigene:4010
HES1 GeneProduct ensembl:ENSG00000114315
CHRNA4 GeneProduct ncbigene:1137
KCNH2 GeneProduct ncbigene:3757
NFYA GeneProduct ncbigene:4800
KCNQ1 GeneProduct ncbigene:3784
ASCL1 GeneProduct ncbigene:429
ESR2 GeneProduct ncbigene:2100
REST GeneProduct ensembl:ENSG00000084093
BHLHE40 GeneProduct ensembl:ENSG00000134107
RORA GeneProduct ncbigene:6095
L-Tryptophan Metabolite hmdb:HMDB0000929
DEAF1 GeneProduct ncbigene:10522
HTR2A GeneProduct ncbigene:3356
SP1 GeneProduct ensembl:ENSG00000185591
ADCYAP1 GeneProduct ncbigene:116
VIPR2 GeneProduct ncbigene:7434
EN1 GeneProduct ncbigene:2019
Glial Cell Differentiation Pathway wikipathways:WP2276
TCF3 GeneProduct ensembl:ENSG00000071564
IL6 GeneProduct ncbigene:3569
YBX1 GeneProduct ncbigene:4904
GATA3 GeneProduct ncbigene:2625
VIPR1 GeneProduct ncbigene:7433
SP1 GeneProduct ensembl:ENSG00000185591
TPH2 GeneProduct ncbigene:121278
Nicotine Metabolite hmdb:HMDB0001934
SLC6A4 GeneProduct ncbigene:6532
TP73 GeneProduct ensembl:ENSG00000078900
CDCA7L GeneProduct ncbigene:55536
HSPD1 GeneProduct ncbigene:3329
POU3F2 GeneProduct ncbigene:5454
FEV GeneProduct ncbigene:54738
SSTR1 GeneProduct ensembl:ENSG00000139874
ECE1 GeneProduct ncbigene:1889
POU3F2 GeneProduct ncbigene:5454
GNB3 GeneProduct ncbigene:2784
MAOA GeneProduct ncbigene:4128
PKNOX1 GeneProduct ensembl:ENSG00000160199
AR GeneProduct ncbigene:367
DDC GeneProduct ncbigene:1644
Fluoxetine Metabolite cas:54910-89-3
PBX1 GeneProduct ensembl:ENSG00000185630
5-HTP Metabolite hmdb:HMDB0000472
FOXM1 GeneProduct ncbigene:2305
IL6R GeneProduct ncbigene:3570
CREB1 GeneProduct ncbigene:1385
TPH2 GeneProduct ncbigene:121278
5-HIAA Metabolite hmdb:HMDB0000763
HTR1A GeneProduct ncbigene:3350
KCNQ1 GeneProduct ncbigene:3784
NR3C1 GeneProduct ncbigene:2908
PHOX2A GeneProduct ncbigene:401
RET GeneProduct ncbigene:5979
SP1 GeneProduct ncbigene:6667
HES5 GeneProduct ncbigene:388585
RYR2 GeneProduct ncbigene:6262
TLX3 GeneProduct ncbigene:30012
NFKB1 GeneProduct ncbigene:4790
NKX2-2 GeneProduct ncbigene:4821
EGR1 GeneProduct ensembl:ENSG00000120738
PHOX2B GeneProduct ncbigene:8929
REST GeneProduct ncbigene:5978
FEV GeneProduct ncbigene:54738
SP1 GeneProduct ensembl:ENSG00000185591
5-HT Metabolite hmdb:HMDB0000259
HIF1A GeneProduct ensembl:ENSG00000100644
5-HT Metabolite hmdb:HMDB0000259
CTNNB1 GeneProduct ensembl:ENSG00000168036
SOX2 GeneProduct ensembl:ENSG00000181449
NANOG GeneProduct ensembl:ENSG00000111704
POU5F1 GeneProduct ensembl:ENSG00000204531
BDNF GeneProduct ensembl:ENSG00000176697
NTRK2 GeneProduct ncbigene:4915
GABA Metabolite hmdb:HMDB0000112
GABRA1 GeneProduct ncbigene:2554
CHRM2 GeneProduct ncbigene:1129
GJA1 GeneProduct ensembl:ENSG00000152661
SNTA1 GeneProduct ncbigene:6640
KCNJ8 GeneProduct ncbigene:3764
GJA1 GeneProduct ensembl:ENSG00000152661
PRKAR2B GeneProduct ncbigene:5577
YWHAE GeneProduct ncbigene:7531
YWHAZ GeneProduct ncbigene:7534
PRKAR1B GeneProduct ncbigene:5575
PRKAR2A GeneProduct ncbigene:5576
YWHAQ GeneProduct ncbigene:10971
YWHAG GeneProduct ncbigene:7532
PRKAR1A GeneProduct ncbigene:5573
YWHAH GeneProduct ncbigene:7533
YWHAB GeneProduct ncbigene:7529
PRKACB GeneProduct ncbigene:5567
PRKACA GeneProduct ncbigene:5566
SLC9A3 GeneProduct ncbigene:6550
CASP3 GeneProduct ensembl:ENSG00000164305
FMO3 GeneProduct ensembl:ENSG00000007933
G6PC GeneProduct ensembl:ENSG00000131482
GCK GeneProduct ensembl:ENSG00000106633
GPD1L GeneProduct ensembl:ENSG00000152642
GRIN1 GeneProduct ensembl:ENSG00000176884
HADHB GeneProduct ensembl:ENSG00000138029
HTR3A GeneProduct ensembl:ENSG00000166736
SCN3B GeneProduct ensembl:ENSG00000166257
SCN4B GeneProduct ensembl:ENSG00000177098
SST GeneProduct ensembl:ENSG00000157005
5-HT Metabolite hmdb:HMDB0000259
Glutamate Metabolite hmdb:HMDB0004135
AQP4 GeneProduct ensembl:ENSG00000171885
CPT1A GeneProduct ensembl:ENSG00000110090
IL1A GeneProduct ensembl:ENSG00000115008
IL1B GeneProduct ensembl:ENSG00000125538
IL1RN GeneProduct ensembl:ENSG00000136689
IL13 GeneProduct ensembl:ENSG00000169194
TSPYL1 GeneProduct ensembl:ENSG00000189241
VEGFA GeneProduct ensembl:ENSG00000112715
SCN5A GeneProduct ncbigene:6331
Dopamine Metabolite cas:62-31-7
Phenylalanine Metabolite cas:63-91-2
CHAT GeneProduct ensembl:ENSG00000070748
L-DOPA Metabolite cas:59-92-7
PAH GeneProduct ncbigene:5053
Acetylcholine Metabolite cas:51-84-3
Choline Metabolite cas:62-49-7
TH GeneProduct ensembl:ENSG00000180176
Tyrosine Metabolite cas:60-18-4
DDC GeneProduct ncbigene:1644
NOS1AP GeneProduct ensembl:ENSG00000198929
MAP2 GeneProduct ensembl:ENSG00000078018
TAC1 GeneProduct ensembl:ENSG00000006128
SLC1A3 GeneProduct ensembl:ENSG00000079215
SLC25A4 GeneProduct ensembl:ENSG00000151729
Glutamate Metabolite hmdb:HMDB0004135
SNAP25 GeneProduct ensembl:ENSG00000132639
Glutamate Metabolite hmdb:HMDB0004135
SST GeneProduct ensembl:ENSG00000157005
TAC1 GeneProduct ensembl:ENSG00000006128
HTR3A GeneProduct ensembl:ENSG00000166736
TH GeneProduct ensembl:ENSG00000180176
CHAT GeneProduct ensembl:ENSG00000070748
SLC9A3 GeneProduct ncbigene:6550
BDNF GeneProduct ensembl:ENSG00000176697
NTRK2 GeneProduct ncbigene:4915
AQP4 GeneProduct ensembl:ENSG00000171885
GRIN1 GeneProduct ensembl:ENSG00000176884
SP1 GeneProduct ensembl:ENSG00000185591
NFKB2 GeneProduct ensembl:ENSG00000077150
JUN GeneProduct ensembl:ENSG00000177606
HDAC9 GeneProduct ensembl:ENSG00000048052
MYB GeneProduct ensembl:ENSG00000118513
CEBPB GeneProduct ensembl:ENSG00000172216
SNTA1 GeneProduct ncbigene:6640
GPD1L GeneProduct ensembl:ENSG00000152642
SP1 GeneProduct ensembl:ENSG00000185591
JUN GeneProduct ensembl:ENSG00000177606
NR3C1 GeneProduct ensembl:ENSG00000113580
REST GeneProduct ensembl:ENSG00000084093
JUN GeneProduct ensembl:ENSG00000177606
CREB1 GeneProduct ensembl:ENSG00000118260
POU2F2 GeneProduct ensembl:ENSG00000028277
CREM GeneProduct ensembl:ENSG00000095794
REST GeneProduct ensembl:ENSG00000084093
NFKB1 GeneProduct ensembl:ENSG00000109320
CHRNB2 GeneProduct ncbigene:1141
CHRNA7 GeneProduct ensembl:ENSG00000175344
HDAC1 GeneProduct ensembl:ENSG00000116478
MBD1 GeneProduct ensembl:ENSG00000141644
MECP2 GeneProduct ensembl:ENSG00000169057
NFKB1 GeneProduct ensembl:ENSG00000109320
CREBBP GeneProduct ensembl:ENSG00000005339
GABRA1 GeneProduct ncbigene:2554
CREB1 GeneProduct ensembl:ENSG00000118260
VAMP2 GeneProduct ensembl:ENSG00000220205
TPPP GeneProduct ensembl:ENSG00000171368
ATP1A3 GeneProduct ensembl:ENSG00000105409
GAPDH GeneProduct ensembl:ENSG00000111640
HSP90B1 GeneProduct ensembl:ENSG00000166598
TF GeneProduct ensembl:ENSG00000091513
SPTBN1 GeneProduct ensembl:ENSG00000115306
YWHAG GeneProduct ensembl:ENSG00000170027
HIF1A GeneProduct ensembl:ENSG00000100644

References

  1. Pérgola PE, Alper RH. Vasopressin and autonomic mechanisms mediate cardiovascular actions of central serotonin. Am J Physiol. 1991 Jun;260(6 Pt 2):R1188-93. PubMed Europe PMC Scholia
  2. Adams ME, Dwyer TM, Dowler LL, White RA, Froehner SC. Mouse alpha 1- and beta 2-syntrophin gene structure, chromosome localization, and homology with a discs large domain. J Biol Chem. 1995 Oct 27;270(43):25859–65. PubMed Europe PMC Scholia
  3. Schmitt M, Bausero P, Simoni P, Queuche D, Geoffroy V, Marschal C, et al. Positive and negative effects of nuclear receptors on transcription activation by AP-1 of the human choline acetyltransferase proximal promoter. J Neurosci Res. 1995 Feb 1;40(2):152–64. PubMed Europe PMC Scholia
  4. Dawson SJ, Yoon SO, Chikaraishi DM, Lillycrop KA, Latchman DS. The Oct-2 transcription factor represses tyrosine hydroxylase expression via a heptamer TAATGARAT-like motif in the gene promoter. Nucleic Acids Res. 1994 Mar 25;22(6):1023–8. PubMed Europe PMC Scholia
  5. Nishida K, Otsu K, Hori M, Kuzuya T, Tada M. Cloning and characterization of the 5’-upstream regulatory region of the Ca(2+)-release channel gene of cardiac sarcoplasmic reticulum. Eur J Biochem. 1996 Sep 1;240(2):408–15. PubMed Europe PMC Scholia
  6. Rahim RA, Boyd PA, Ainslie Patrick WJ, Burdon RH. Human heat shock protein gene polymorphisms and sudden infant death syndrome. Arch Dis Child. 1996 Nov;75(5):451–2. PubMed Europe PMC Scholia
  7. Nagamoto-Combs K, Piech KM, Best JA, Sun B, Tank AW. Tyrosine hydroxylase gene promoter activity is regulated by both cyclic AMP-responsive element and AP1 sites following calcium influx. Evidence for cyclic amp-responsive element binding protein-independent regulation. J Biol Chem. 1997 Feb 28;272(9):6051–8. PubMed Europe PMC Scholia
  8. Orii KE, Aoyama T, Wakui K, Fukushima Y, Miyajima H, Yamaguchi S, et al. Genomic and mutational analysis of the mitochondrial trifunctional protein beta-subunit (HADHB) gene in patients with trifunctional protein deficiency. Hum Mol Genet. 1997 Aug;6(8):1215–24. PubMed Europe PMC Scholia
  9. Raynal JF, Dugast C, Le Van Thaï A, Weber MJ. Winged helix hepatocyte nuclear factor 3 and POU-domain protein brn-2/N-oct-3 bind overlapping sites on the neuronal promoter of human aromatic L-amino acid decarboxylase gene. Brain Res Mol Brain Res. 1998 May;56(1–2):227–37. PubMed Europe PMC Scholia
  10. Teerawatanasuk N, Carr LG. CBF/NF-Y activates transcription of the human tryptophan hydroxylase gene through an inverted CCAAT box. Brain Res Mol Brain Res. 1998 Mar 30;55(1):61–70. PubMed Europe PMC Scholia
  11. Umenishi F, Verkman AS. Isolation and functional analysis of alternative promoters in the human aquaporin-4 water channel gene. Genomics. 1998 Jun 15;50(3):373–7. PubMed Europe PMC Scholia
  12. Goudet G, Delhalle S, Biemar F, Martial JA, Peers B. Functional and cooperative interactions between the homeodomain PDX1, Pbx, and Prep1 factors on the somatostatin promoter. J Biol Chem. 1999 Feb 12;274(7):4067–73. PubMed Europe PMC Scholia
  13. Opdal SH, Vege A, Stave AK, Rognum TO. The complement component C4 in sudden infant death. Eur J Pediatr. 1999 Mar;158(3):210–2. PubMed Europe PMC Scholia
  14. Mallard C, Tolcos M, Leditschke J, Campbell P, Rees S. Reduction in choline acetyltransferase immunoreactivity but not muscarinic-m2 receptor immunoreactivity in the brainstem of SIDS infants. J Neuropathol Exp Neurol. 1999 Mar;58(3):255–64. PubMed Europe PMC Scholia
  15. Echetebu CO, Ali M, Izban MG, MacKay L, Garfield RE. Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene. Mol Hum Reprod. 1999 Aug;5(8):757–66. PubMed Europe PMC Scholia
  16. Hendricks T, Francis N, Fyodorov D, Deneris ES. The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. J Neurosci. 1999 Dec 1;19(23):10348–56. PubMed Europe PMC Scholia
  17. Pombo PM, Barettino D, Espliguero G, Metsis M, Iglesias T, Rodriguez-Pena A. Transcriptional repression of neurotrophin receptor trkB by thyroid hormone in the developing rat brain. J Biol Chem. 2000 Dec 1;275(48):37510–7. PubMed Europe PMC Scholia
  18. Toliver-Kinsky T, Wood T, Perez-Polo JR. Nuclear factor kappaB/p49 is a negative regulatory factor in nerve growth factor-induced choline acetyltransferase promoter activity in PC12 cells. J Neurochem. 2000 Dec;75(6):2241–51. PubMed Europe PMC Scholia
  19. Côté F, Schussler N, Boularand S, Peirotes A, Thévenot E, Mallet J, et al. Involvement of NF-Y and Sp1 in basal and cAMP-stimulated transcriptional activation of the tryptophan hydroxylase (TPH ) gene in the pineal gland. J Neurochem. 2002 May;81(4):673–85. PubMed Europe PMC Scholia
  20. Robert I, Sutter A, Quirin-Stricker C. Synergistic activation of the human choline acetyltransferase gene by c-Myb and C/EBPbeta. Brain Res Mol Brain Res. 2002 Oct 15;106(1–2):124–35. PubMed Europe PMC Scholia
  21. Machaalani R, Waters KA. NMDA receptor 1 expression in the brainstem of human infants and its relevance to the sudden infant death syndrome (SIDS). J Neuropathol Exp Neurol. 2003 Oct;62(10):1076–85. PubMed Europe PMC Scholia
  22. Cummings KJ, Pendlebury JD, Sherwood NM, Wilson RJA. Sudden neonatal death in PACAP-deficient mice is associated with reduced respiratory chemoresponse and susceptibility to apnoea. J Physiol. 2004 Feb 15;555(Pt 1):15–26. PubMed Europe PMC Scholia
  23. Sawaguchi T, Patricia F, Kadhim H, Groswasser J, Sottiaux M, Nishida H, et al. The correlation between microtubule-associated protein 2 in the brainstem of SIDS victims and physiological data on sleep apnea. Early Hum Dev. 2003 Dec;75 Suppl:S87-97. PubMed Europe PMC Scholia
  24. Dugast-Darzacq C, Egloff S, Weber MJ. Cooperative dimerization of the POU domain protein Brn-2 on a new motif activates the neuronal promoter of the human aromatic L-amino acid decarboxylase gene. Brain Res Mol Brain Res. 2004 Jan 5;120(2):151–63. PubMed Europe PMC Scholia
  25. Lemonde S, Rogaeva A, Albert PR. Cell type-dependent recruitment of trichostatin A-sensitive repression of the human 5-HT1A receptor gene. J Neurochem. 2004 Feb;88(4):857–68. PubMed Europe PMC Scholia
  26. Miyata A, Sugawara H, Iwata S, Shimizu T, Kangawa K. The regulatory mechanism for neuron specific expression of PACAP gene. Nihon Yakurigaku Zasshi. 2004 Apr;123(4):235–42. PubMed Europe PMC Scholia
  27. Lau P, Nixon SJ, Parton RG, Muscat GEO. RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR. J Biol Chem. 2004 Aug 27;279(35):36828–40. PubMed Europe PMC Scholia
  28. Weese-Mayer DE, Berry-Kravis EM, Zhou L, Maher BS, Curran ME, Silvestri JM, et al. Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic development. Pediatr Res. 2004 Sep;56(3):391–5. PubMed Europe PMC Scholia
  29. Puffenberger EG, Hu-Lince D, Parod JM, Craig DW, Dobrin SE, Conway AR, et al. Mapping of sudden infant death with dysgenesis of the testes syndrome (SIDDT) by a SNP genome scan and identification of TSPYL loss of function. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11689–94. PubMed Europe PMC Scholia
  30. Lavezzi AM, Ottaviani G, Matturri L. Role of somatostatin and apoptosis in breathing control in sudden perinatal and infant unexplained death. Clin Neuropathol. 2004;23(6):304–10. PubMed Europe PMC Scholia
  31. Scott MM, Krueger KC, Deneris ES. A differentially autoregulated Pet-1 enhancer region is a critical target of the transcriptional cascade that governs serotonin neuron development. J Neurosci. 2005 Mar 9;25(10):2628–36. PubMed Europe PMC Scholia
  32. Forsyth L, Hume R, Howatson A, Busuttil A, Burchell A. Identification of novel polymorphisms in the glucokinase and glucose-6-phosphatase genes in infants who died suddenly and unexpectedly. J Mol Med (Berl). 2005 Aug;83(8):610–8. PubMed Europe PMC Scholia
  33. Fukuchi M, Tabuchi A, Tsuda M. Transcriptional regulation of neuronal genes and its effect on neural functions: cumulative mRNA expression of PACAP and BDNF genes controlled by calcium and cAMP signals in neurons. J Pharmacol Sci. 2005 Jul;98(3):212–8. PubMed Europe PMC Scholia
  34. Derry C, Benjamin C, Bladin P, le Bars D, Tochon-Danguy H, Berkovic SF, et al. Increased serotonin receptor availability in human sleep: evidence from an [18F]MPPF PET study in narcolepsy. Neuroimage. 2006 Apr 1;30(2):341–8. PubMed Europe PMC Scholia
  35. Czesak M, Lemonde S, Peterson EA, Rogaeva A, Albert PR. Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphism. J Neurosci. 2006 Feb 8;26(6):1864–71. PubMed Europe PMC Scholia
  36. Ou X-M, Chen K, Shih JC. Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1. J Biol Chem. 2006 Jul 28;281(30):21512–25. PubMed Europe PMC Scholia
  37. Kim SM, Yang JW, Park MJ, Lee J-K, Kim SU, Lee YS, et al. Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor. Biochem Biophys Res Commun. 2006 Jul 28;346(2):426–35. PubMed Europe PMC Scholia
  38. Rand CM, Weese-Mayer DE, Zhou L, Maher BS, Cooper ME, Marazita ML, et al. Sudden infant death syndrome: Case-control frequency differences in paired like homeobox (PHOX) 2B gene. Am J Med Genet A. 2006 Aug 1;140(15):1687–91. PubMed Europe PMC Scholia
  39. Player A, Wang Y, Bhattacharya B, Rao M, Puri RK, Kawasaki ES. Comparisons between transcriptional regulation and RNA expression in human embryonic stem cell lines. Stem Cells Dev. 2006 Jun;15(3):315–23. PubMed Europe PMC Scholia
  40. Dashash M, Pravica V, Hutchinson IV, Barson AJ, Drucker DB. Association of sudden infant death syndrome with VEGF and IL-6 gene polymorphisms. Hum Immunol. 2006 Aug;67(8):627–33. PubMed Europe PMC Scholia
  41. Bhat KMR, Maddodi N, Shashikant C, Setaluri V. Transcriptional regulation of human MAP2 gene in melanoma: role of neuronal bHLH factors and Notch1 signaling. Nucleic Acids Res. 2006 Aug 11;34(13):3819–32. PubMed Europe PMC Scholia
  42. Hauge Opdal S, Melien Ø, Rootwelt H, Vege A, Arnestad M, Ole Rognum T. The G protein beta3 subunit 825C allele is associated with sudden infant death due to infection. Acta Paediatr. 2006 Sep;95(9):1129–32. PubMed Europe PMC Scholia
  43. Paterson DS, Trachtenberg FL, Thompson EG, Belliveau RA, Beggs AH, Darnall R, et al. Multiple serotonergic brainstem abnormalities in sudden infant death syndrome. JAMA. 2006 Nov 1;296(17):2124–32. PubMed Europe PMC Scholia
  44. Van Hoecke M, Prigent-Tessier AS, Garnier PE, Bertrand NM, Filomenko R, Bettaieb A, et al. Evidence of HIF-1 functional binding activity to caspase-3 promoter after photothrombotic cerebral ischemia. Mol Cell Neurosci. 2007 Jan;34(1):40–7. PubMed Europe PMC Scholia
  45. Lin H, Xiao J, Luo X, Wang H, Gao H, Yang B, et al. Overexpression HERG K(+) channel gene mediates cell-growth signals on activation of oncoproteins SP1 and NF-kappaB and inactivation of tumor suppressor Nkx3.1. J Cell Physiol. 2007 Jul;212(1):137–47. PubMed Europe PMC Scholia
  46. Forsyth L, Scott HM, Howatson A, Busuttil A, Hume R, Burchell A. Genetic variation in hepatic glucose-6-phosphatase system genes in cases of sudden infant death syndrome. J Pathol. 2007 May;212(1):112–20. PubMed Europe PMC Scholia
  47. Roberts J, Scott AC, Howard MR, Breen G, Bubb VJ, Klenova E, et al. Differential regulation of the serotonin transporter gene by lithium is mediated by transcription factors, CCCTC binding protein and Y-box binding protein 1, through the polymorphic intron 2 variable number tandem repeat. J Neurosci. 2007 Mar 14;27(11):2793–801. PubMed Europe PMC Scholia
  48. Martens LK, Kirschner KM, Warnecke C, Scholz H. Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator of the TrkB neurotrophin receptor gene. J Biol Chem. 2007 May 11;282(19):14379–88. PubMed Europe PMC Scholia
  49. Kingsbury TJ, Krueger BK. Ca2+, CREB and krüppel: a novel KLF7-binding element conserved in mouse and human TRKB promoters is required for CREB-dependent transcription. Mol Cell Neurosci. 2007 Jul;35(3):447–55. PubMed Europe PMC Scholia
  50. Tester DJ, Dura M, Carturan E, Reiken S, Wronska A, Marks AR, et al. A mechanism for sudden infant death syndrome (SIDS): stress-induced leak via ryanodine receptors. Heart Rhythm. 2007 Jun;4(6):733–9. PubMed Europe PMC Scholia
  51. Scheuch K, Lautenschlager M, Grohmann M, Stahlberg S, Kirchheiner J, Zill P, et al. Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biol Psychiatry. 2007 Dec 1;62(11):1288–94. PubMed Europe PMC Scholia
  52. Inoue K, Ito K, Osato M, Lee B, Bae S-C, Ito Y. The transcription factor Runx3 represses the neurotrophin receptor TrkB during lineage commitment of dorsal root ganglion neurons. J Biol Chem. 2007 Aug 17;282(33):24175–84. PubMed Europe PMC Scholia
  53. Rand CM, Berry-Kravis EM, Zhou L, Fan W, Weese-Mayer DE. Sudden infant death syndrome: rare mutation in the serotonin system FEV gene. Pediatr Res. 2007 Aug;62(2):180–2. PubMed Europe PMC Scholia
  54. Patel PD, Bochar DA, Turner DL, Meng F, Mueller HM, Pontrello CG. Regulation of tryptophan hydroxylase-2 gene expression by a bipartite RE-1 silencer of transcription/neuron restrictive silencing factor (REST/NRSF) binding motif. J Biol Chem. 2007 Sep 14;282(37):26717–24. PubMed Europe PMC Scholia
  55. Greco SJ, Smirnov SV, Murthy RG, Rameshwar P. Synergy between the RE-1 silencer of transcription and NFkappaB in the repression of the neurotransmitter gene TAC1 in human mesenchymal stem cells. J Biol Chem. 2007 Oct 12;282(41):30039–50. PubMed Europe PMC Scholia
  56. Dergacheva O, Griffioen KJS, Wang X, Kamendi H, Gorini C, Mendelowitz D. 5-HT(2) receptor subtypes mediate different long-term changes in GABAergic activity to parasympathetic cardiac vagal neurons in the nucleus ambiguus. Neuroscience. 2007 Nov 9;149(3):696–705. PubMed Europe PMC Scholia
  57. Winge I, McKinney JA, Ying M, D’Santos CS, Kleppe R, Knappskog PM, et al. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. Biochem J. 2008 Feb 15;410(1):195–204. PubMed Europe PMC Scholia
  58. Shang LL, Sanyal S, Pfahnl AE, Jiao Z, Allen J, Liu H, et al. NF-kappaB-dependent transcriptional regulation of the cardiac scn5a sodium channel by angiotensin II. Am J Physiol Cell Physiol. 2008 Jan;294(1):C372-9. PubMed Europe PMC Scholia
  59. Yang Z, Lantz PE, Ibdah JA. Post-mortem analysis for two prevalent beta-oxidation mutations in sudden infant death. Pediatr Int. 2007 Dec;49(6):883–7. PubMed Europe PMC Scholia
  60. Machaalani R, Waters KA. Neuronal cell death in the Sudden Infant Death Syndrome brainstem and associations with risk factors. Brain. 2008 Jan;131(Pt 1):218–28. PubMed Europe PMC Scholia
  61. Wiemann M, Frede S, Tschentscher F, Kiwull-Schöne H, Kiwull P, Bingmann D, et al. NHE3 in the human brainstem: implication for the pathogenesis of the sudden infant death syndrome (SIDS)? Adv Exp Med Biol. 2008;605:508–13. PubMed Europe PMC Scholia
  62. Brown JW, Sirlin EA, Benoit AM, Hoffman JM, Darnall RA. Activation of 5-HT1A receptors in medullary raphé disrupts sleep and decreases shivering during cooling in the conscious piglet. Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R884-94. PubMed Europe PMC Scholia
  63. Hu Y, Lund IV, Gravielle MC, Farb DH, Brooks-Kayal AR, Russek SJ. Surface expression of GABAA receptors is transcriptionally controlled by the interplay of cAMP-response element-binding protein and its binding partner inducible cAMP early repressor. J Biol Chem. 2008 Apr 4;283(14):9328–40. PubMed Europe PMC Scholia
  64. Luo X, Xiao J, Lin H, Lu Y, Yang B, Wang Z. Genomic structure, transcriptional control, and tissue distribution of HERG1 and KCNQ1 genes. Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1371-80. PubMed Europe PMC Scholia
  65. Jiang X, Tian F, Du Y, Copeland NG, Jenkins NA, Tessarollo L, et al. BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability. J Neurosci. 2008 Jan 30;28(5):1118–30. PubMed Europe PMC Scholia
  66. Sudhakar C, Jain N, Swarup G. Sp1-like sequences mediate human caspase-3 promoter activation by p73 and cisplatin. FEBS J. 2008 May;275(9):2200–13. PubMed Europe PMC Scholia
  67. Klintschar M, Reichenpfader B, Saternus K-S. A functional polymorphism in the tyrosine hydroxylase gene indicates a role of noradrenalinergic signaling in sudden infant death syndrome. J Pediatr. 2008 Aug;153(2):190–3. PubMed Europe PMC Scholia
  68. Ferrante L, Opdal SH, Vege A, Rognum TO. TNF-alpha promoter polymorphisms in sudden infant death. Hum Immunol. 2008 Jun;69(6):368–73. PubMed Europe PMC Scholia
  69. Audero E, Coppi E, Mlinar B, Rossetti T, Caprioli A, Banchaabouchi MA, et al. Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. Science. 2008 Jul 4;321(5885):130–3. PubMed Europe PMC Scholia
  70. Perskvist N, Skoglund K, Edston E, Bäckström G, Lodestad I, Palm U. TNF-alpha and IL-10 gene polymorphisms versus cardioimmunological responses in sudden infant death. Fetal Pediatr Pathol. 2008;27(3):149–65. PubMed Europe PMC Scholia
  71. Le François B, Czesak M, Steubl D, Albert PR. Transcriptional regulation at a HTR1A polymorphism associated with mental illness. Neuropharmacology. 2008 Nov;55(6):977–85. PubMed Europe PMC Scholia
  72. Gallego J, Dauger S. PHOX2B mutations and ventilatory control. Respir Physiol Neurobiol. 2008 Dec 10;164(1–2):49–54. PubMed Europe PMC Scholia
  73. Semba J, Wakuta M. Chronic effect of nicotine on serotonin transporter mRNA in the raphe nucleus of rats: reversal by co-administration of bupropion. Psychiatry Clin Neurosci. 2008 Aug;62(4):435–41. PubMed Europe PMC Scholia
  74. Galehdari H, Pooryasin A, Foroughmand A, Daneshmand S, Saadat M. Association between the G1001C polymorphism in the GRIN1 gene promoter and schizophrenia in the Iranian population. J Mol Neurosci. 2009 Jun;38(2):178–81. PubMed Europe PMC Scholia
  75. Filonzi L, Magnani C, Lavezzi AM, Rindi G, Parmigiani S, Bevilacqua G, et al. Association of dopamine transporter and monoamine oxidase molecular polymorphisms with sudden infant death syndrome and stillbirth: new insights into the serotonin hypothesis. Neurogenetics. 2009 Feb;10(1):65–72. PubMed Europe PMC Scholia
  76. Tester DJ, Ackerman MJ. Cardiomyopathic and channelopathic causes of sudden unexplained death in infants and children. Annu Rev Med. 2009;60:69–84. PubMed Europe PMC Scholia
  77. Cummings KJ, Klotz C, Liu W-Q, Weese-Mayer DE, Marazita ML, Cooper ME, et al. Sudden infant death syndrome (SIDS) in African Americans: polymorphisms in the gene encoding the stress peptide pituitary adenylate cyclase-activating polypeptide (PACAP). Acta Paediatr. 2009 Mar;98(3):482–9. PubMed Europe PMC Scholia
  78. Dergacheva O, Kamendi H, Wang X, Pinol RM, Frank J, Jameson H, et al. The role of 5-HT3 and other excitatory receptors in central cardiorespiratory responses to hypoxia: implications for sudden infant death syndrome. Pediatr Res. 2009 Jun;65(6):625–30. PubMed Europe PMC Scholia
  79. Sullivan GM, Ogden RT, Oquendo MA, Kumar JSD, Simpson N, Huang Y, et al. Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression. Biol Psychiatry. 2009 Aug 1;66(3):223–30. PubMed Europe PMC Scholia
  80. Osawa M, Kimura R, Hasegawa I, Mukasa N, Satoh F. SNP association and sequence analysis of the NOS1AP gene in SIDS. Leg Med (Tokyo). 2009 Apr;11 Suppl 1:S307-8. PubMed Europe PMC Scholia
  81. Lavezzi AM, Casale V, Oneda R, Weese-Mayer DE, Matturri L. Sudden infant death syndrome and sudden intrauterine unexplained death: correlation between hypoplasia of raphé nuclei and serotonin transporter gene promoter polymorphism. Pediatr Res. 2009 Jul;66(1):22–7. PubMed Europe PMC Scholia
  82. Cummings KJ, Commons KG, Fan KC, Li A, Nattie EE. Severe spontaneous bradycardia associated with respiratory disruptions in rat pups with fewer brain stem 5-HT neurons. Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1783-96. PubMed Europe PMC Scholia
  83. Rognum IJ, Haynes RL, Vege A, Yang M, Rognum TO, Kinney HC. Interleukin-6 and the serotonergic system of the medulla oblongata in the sudden infant death syndrome. Acta Neuropathol. 2009 Oct;118(4):519–30. PubMed Europe PMC Scholia
  84. Tian F, Hu X-Z, Wu X, Jiang H, Pan H, Marini AM, et al. Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1. J Neurochem. 2009 Jun;109(5):1375–88. PubMed Europe PMC Scholia
  85. Donner N, Handa RJ. Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat dorsal raphe nuclei. Neuroscience. 2009 Oct 6;163(2):705–18. PubMed Europe PMC Scholia
  86. Valdivia CR, Ueda K, Ackerman MJ, Makielski JC. GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A. Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1446-52. PubMed Europe PMC Scholia
  87. Duncan JR, Garland M, Myers MM, Fifer WP, Yang M, Kinney HC, et al. Prenatal nicotine-exposure alters fetal autonomic activity and medullary neurotransmitter receptors: implications for sudden infant death syndrome. J Appl Physiol (1985). 2009 Nov;107(5):1579–90. PubMed Europe PMC Scholia
  88. Poetsch M, Nottebaum BJ, Wingenfeld L, Frede S, Vennemann M, Bajanowski T. Impact of sodium/proton exchanger 3 gene variants on sudden infant death syndrome. J Pediatr. 2010 Jan;156(1):44-48.e1. PubMed Europe PMC Scholia
  89. Pedraza N, Rafel M, Navarro I, Encinas M, Aldea M, Gallego C. Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways. J Biol Chem. 2009 Nov 20;284(47):32980–8. PubMed Europe PMC Scholia
  90. Xia X, Batra N, Shi Q, Bonewald LF, Sprague E, Jiang JX. Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of connexin 43 by glycogen synthase kinase 3/beta-catenin signaling. Mol Cell Biol. 2010 Jan;30(1):206–19. PubMed Europe PMC Scholia
  91. Maddodi N, Bhat KMR, Devi S, Zhang S-C, Setaluri V. Oncogenic BRAFV600E induces expression of neuronal differentiation marker MAP2 in melanoma cells by promoter demethylation and down-regulation of transcription repressor HES1. J Biol Chem. 2010 Jan 1;285(1):242–54. PubMed Europe PMC Scholia
  92. Ferrante L, Opdal SH, Vege A, Rognum T. Cytokine gene polymorphisms and sudden infant death syndrome. Acta Paediatr. 2010 Mar;99(3):384–8. PubMed Europe PMC Scholia
  93. Cheng J, Van Norstrand DW, Medeiros-Domingo A, Valdivia C, Tan B, Ye B, et al. Alpha1-syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current. Circ Arrhythm Electrophysiol. 2009 Dec;2(6):667–76. PubMed Europe PMC Scholia
  94. Ferrante L, Opdal SH, Vege A, Rognum TO. IL-1 gene cluster polymorphisms and sudden infant death syndrome. Hum Immunol. 2010 Apr;71(4):402–6. PubMed Europe PMC Scholia
  95. Duncan JR, Paterson DS, Hoffman JM, Mokler DJ, Borenstein NS, Belliveau RA, et al. Brainstem serotonergic deficiency in sudden infant death syndrome. JAMA. 2010 Feb 3;303(5):430–7. PubMed Europe PMC Scholia
  96. Poetsch M, Czerwinski M, Wingenfeld L, Vennemann M, Bajanowski T. A common FMO3 polymorphism may amplify the effect of nicotine exposure in sudden infant death syndrome (SIDS). Int J Legal Med. 2010 Jul;124(4):301–6. PubMed Europe PMC Scholia
  97. Livolsi A, Niederhoffer N, Dali-Youcef N, Rambaud C, Olexa C, Mokni W, et al. Cardiac muscarinic receptor overexpression in sudden infant death syndrome. PLoS One. 2010 Mar 1;5(3):e9464. PubMed Europe PMC Scholia
  98. Tan B-H, Pundi KN, Van Norstrand DW, Valdivia CR, Tester DJ, Medeiros-Domingo A, et al. Sudden infant death syndrome-associated mutations in the sodium channel beta subunits. Heart Rhythm. 2010 Jun;7(6):771–8. PubMed Europe PMC Scholia
  99. Opdal SH, Vege A, Stray-Pedersen A, Rognum TO. Aquaporin-4 gene variation and sudden infant death syndrome. Pediatr Res. 2010 Jul;68(1):48–51. PubMed Europe PMC Scholia
  100. Baudry A, Mouillet-Richard S, Schneider B, Launay J-M, Kellermann O. miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants. Science. 2010 Sep 17;329(5998):1537–41. PubMed Europe PMC Scholia
  101. Highet AR, Gibson CS, Goldwater PN. Variant interleukin 1 receptor antagonist gene alleles in sudden infant death syndrome. Arch Dis Child. 2010 Dec;95(12):1009–12. PubMed Europe PMC Scholia
  102. Gessner BD, Gillingham MB, Birch S, Wood T, Koeller DM. Evidence for an association between infant mortality and a carnitine palmitoyltransferase 1A genetic variant. Pediatrics. 2010 Nov;126(5):945–51. PubMed Europe PMC Scholia
  103. Fukuchi M, Fujii H, Takachi H, Ichinose H, Kuwana Y, Tabuchi A, et al. Activation of tyrosine hydroxylase (TH) gene transcription induced by brain-derived neurotrophic factor (BDNF) and its selective inhibition through Ca(2+) signals evoked via the N-methyl-D-aspartate (NMDA) receptor. Brain Res. 2010 Dec 17;1366:18–26. PubMed Europe PMC Scholia
  104. Bai G, Hoffman PW. Transcriptional Regulation of NMDA Receptor Expression. In: Van Dongen AM, editor. Biology of the NMDA Receptor. Boca Raton (FL): CRC Press/Taylor & Francis; PubMed Europe PMC Scholia
  105. Kelly TJ, Souza AL, Clish CB, Puigserver P. A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like. Mol Cell Biol. 2011 Jul;31(13):2696–706. PubMed Europe PMC Scholia
  106. Queiroz-Leite GD, Peruzzetto MC, Neri EA, Rebouças NA. Transcriptional regulation of the Na⁺/H⁺ exchanger NHE3 by chronic exposure to angiotensin II in renal epithelial cells. Biochem Biophys Res Commun. 2011 Jun 10;409(3):470–6. PubMed Europe PMC Scholia
  107. Tester DJ, Tan B-H, Medeiros-Domingo A, Song C, Makielski JC, Ackerman MJ. Loss-of-function mutations in the KCNJ8-encoded Kir6.1 K(ATP) channel and sudden infant death syndrome. Circ Cardiovasc Genet. 2011 Oct;4(5):510–5. PubMed Europe PMC Scholia
  108. Broadbelt KG, Paterson DS, Belliveau RA, Trachtenberg FL, Haas EA, Stanley C, et al. Decreased GABAA receptor binding in the medullary serotonergic system in the sudden infant death syndrome. J Neuropathol Exp Neurol. 2011 Sep;70(9):799–810. PubMed Europe PMC Scholia
  109. Broadbelt KG, Rivera KD, Paterson DS, Duncan JR, Trachtenberg FL, Paulo JA, et al. Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome. Mol Cell Proteomics. 2012 Jan;11(1):M111.009530. PubMed Europe PMC Scholia
  110. Machaalani R, Say M, Waters KA. Effects of cigarette smoke exposure on nicotinic acetylcholine receptor subunits α7 and β2 in the sudden infant death syndrome (SIDS) brainstem. Toxicol Appl Pharmacol. 2011 Dec 15;257(3):396–404. PubMed Europe PMC Scholia
  111. Van Norstrand DW, Asimaki A, Rubinos C, Dolmatova E, Srinivas M, Tester DJ, et al. Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death. Circulation. 2012 Jan 24;125(3):474–81. PubMed Europe PMC Scholia
  112. Aizawa S, Teramoto K, Yamamuro Y. Histone deacetylase 9 as a negative regulator for choline acetyltransferase gene in NG108-15 neuronal cells. Neuroscience. 2012 Mar 15;205:63–72. PubMed Europe PMC Scholia
  113. Sepramaniam S, Ying LK, Armugam A, Wintour EM, Jeyaseelan K. MicroRNA-130a represses transcriptional activity of aquaporin 4 M1 promoter. J Biol Chem. 2012 Apr 6;287(15):12006–15. PubMed Europe PMC Scholia
  114. Klintschar M, Heimbold C. Association between a functional polymorphism in the MAOA gene and sudden infant death syndrome. Pediatrics. 2012 Mar;129(3):e756-61. PubMed Europe PMC Scholia
  115. Noh K-M, Hwang J-Y, Follenzi A, Athanasiadou R, Miyawaki T, Greally JM, et al. Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):E962-71. PubMed Europe PMC Scholia