DNA damage response (WP707)

This is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two central genes can be divides furthermore into their most important genes. In the ATM pathway are the most important genes TP53 and CHEK2 and on the other hand in the ATR pathway is this CHEK1. If it is not mentioned different, the processes take place in the cell cytoplasm. The goal of this first pathway is to give an overview of the most important gene products, processes and changes in the cell condition through the DNA damage response pathway and at the same time to keep it clearly arranged. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP707 CPTAC Assay Portal]
last edited

Authors

I379077, AlexanderPico, MaintBot, Stan.gaj, Mkutmon, MartijnVanIersel, Christine Chichester, Ddigles, Khanspers, Zari, Egonw, Ryanmiller, Finterly, and Eweitz

Cited In

Organism

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology: p53 signaling pathway DNA damage response pathway stress response pathway

Participants

Label Type Compact Identifier
RB1 GeneProduct ensembl:ENSG00000139687
Cell survival Pathway None
DNA repair anddamage prevention Pathway None
DNA damage ATM dependent Pathway wikipathways:WP710
CDC25C GeneProduct ensembl:ENSG00000158402
CASP8 GeneProduct ensembl:ENSG00000064012
HUS1 GeneProduct ensembl:ENSG00000188996
CCNB1 GeneProduct ensembl:ENSG00000134057
MRE11 GeneProduct ncbigene:4361
CHEK1 GeneProduct ensembl:ENSG00000149554
ATR GeneProduct ensembl:ENSG00000175054
Caffeine Metabolite chemspider:2424
G1/S transition Pathway wikipathways:WP45
CDKN1A GeneProduct ensembl:ENSG00000124762
RAD52 GeneProduct ensembl:ENSG00000002016
c-Myc GeneProduct ncbigene:4609
CASP3 GeneProduct ensembl:ENSG00000164305
MDM2 GeneProduct ensembl:ENSG00000135679
CDK6 GeneProduct ensembl:ENSG00000105810
DDB2 GeneProduct ensembl:ENSG00000134574
PML GeneProduct ensembl:ENSG00000140464
CCND3 GeneProduct ensembl:ENSG00000112576
BID GeneProduct ensembl:ENSG00000015475
TP53AIP1 GeneProduct ensembl:ENSG00000120471
H2AFX GeneProduct ensembl:ENSG00000188486
RAD1 GeneProduct ensembl:ENSG00000113456
FANCD2 GeneProduct ensembl:ENSG00000144554
GADD45A GeneProduct ensembl:ENSG00000116717
FAS GeneProduct ensembl:ENSG00000026103
PIDD GeneProduct ncbigene:55367
CCND1 GeneProduct ensembl:ENSG00000110092
Cell Cycle Pathway wikipathways:WP179
RAD9A GeneProduct ensembl:ENSG00000172613
CYCS GeneProduct ensembl:ENSG00000172115
CDC2 GeneProduct ensembl:ENSG00000170312
GADD45B GeneProduct ensembl:ENSG00000099860
RB1 GeneProduct ensembl:ENSG00000139687
CDK5 GeneProduct ensembl:ENSG00000164885
7-hydroxystaurosporine Metabolite chemspider:65225
PMAIP1 GeneProduct ensembl:ENSG00000141682
CCNB3 GeneProduct ensembl:ENSG00000147082
SESN1 GeneProduct ensembl:ENSG00000080546
RAD51 GeneProduct ensembl:ENSG00000051180
RRM2B GeneProduct ensembl:ENSG00000048392
CDKN1B GeneProduct ensembl:ENSG00000111276
CDK2 GeneProduct ensembl:ENSG00000123374
GADD45G GeneProduct ensembl:ENSG00000130222
SFN GeneProduct ensembl:ENSG00000175793
ATRIP GeneProduct ncbigene:84126
BBC3 GeneProduct ensembl:ENSG00000105327
RPA2 GeneProduct ensembl:ENSG00000117748
RAD50 GeneProduct ensembl:ENSG00000113522
TP53 GeneProduct ensembl:ENSG00000141510
TLK1 GeneProduct ensembl:ENSG00000198586
CDK4 GeneProduct ensembl:ENSG00000135446
CCNE1 GeneProduct ensembl:ENSG00000105173
TNFRSF10B GeneProduct ensembl:ENSG00000120889
GADD45G GeneProduct ensembl:ENSG00000130222
BAX GeneProduct ensembl:ENSG00000087088
RAD17 GeneProduct ensembl:ENSG00000152942
BRCA1 GeneProduct ensembl:ENSG00000012048
CHEK2 GeneProduct ensembl:ENSG00000183765
SMC1A GeneProduct ensembl:ENSG00000072501
Estradiol Metabolite chebi:16469
CREB GeneProduct ncbigene:1385
ABL1 GeneProduct ensembl:ENSG00000097007
E2F1 GeneProduct ensembl:ENSG00000101412
PRKDC GeneProduct ensembl:ENSG00000253729
APAF1 GeneProduct ensembl:ENSG00000120868
CASP9 GeneProduct ensembl:ENSG00000132906
CCNB2 GeneProduct ensembl:ENSG00000157456
E2F1 GeneProduct ensembl:ENSG00000101412
TLK2 GeneProduct ensembl:ENSG00000146872
CDC25A GeneProduct ensembl:ENSG00000164045
NBN GeneProduct ncbigene:4683
GADD45B GeneProduct ensembl:ENSG00000099860
CCNE2 GeneProduct ensembl:ENSG00000175305
CCND2 GeneProduct ensembl:ENSG00000118971
Senescence Pathway wikipathways:WP615
GADD45A GeneProduct ensembl:ENSG00000116717
Apoptosis Pathway wikipathways:WP254
alkylating agents Metabolite chebi:22333
ATM GeneProduct ensembl:ENSG00000149311
RFC GeneProduct ncbigene:5981

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