Estrogen signaling pathway (WP712)

Estrogen receptor refers to a group of receptors which are activated by the hormone 17-beta-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited


Lauravanzon, Khanspers, MaintBot, Vtriver6, Jildau, AlexanderPico, and L Dupuis

Cited In


Homo sapiens



Pathway Ontology: estrogen signaling pathway


Label Type Compact Identifier
C-FOS GeneProduct ncbigene:2353
SP1 GeneProduct ncbigene:6667
ERE GeneProduct ncbigene:2099
Estradiol Metabolite hmdb:HMDB0000151
ER-AF1 GeneProduct ncbigene:2099
ELK GeneProduct ncbigene:2002
ERK 1/2 GeneProduct ensembl:ENSG00000100030
ER GeneProduct ncbigene:2099
ER-AF2 GeneProduct ncbigene:2099
Estradiol Metabolite hmdb:HMDB0000151
GPR30 GeneProduct ncbigene:2852
c-Jun GeneProduct ncbigene:3725
PI3K GeneProduct ncbigene:5290
Estradiol Metabolite hmdb:HMDB0000151
Growth factors Metabolite hmdb:HMDB0000151
NFKB GeneProduct ncbigene:4790
Non-ERE GeneProduct ncbigene:2099
BCL2 Apoptotic switch GeneProduct ncbigene:596
GFRs GeneProduct ncbigene:2099
GNGT1 GeneProduct ncbigene:2792
Cyclic AMP Metabolite hmdb:HMDB0000058
GNB1 GeneProduct ncbigene:2782
PKB/Akt GeneProduct ncbigene:207
CREB GeneProduct ncbigene:1385
MAPKKK GeneProduct ncbigene:673
JNKs GeneProduct ncbigene:5601
ER GeneProduct ncbigene:2099
GSA GeneProduct ncbigene:2778
p38 GeneProduct ncbigene:1432
MAPKK GeneProduct ensembl:ENSG00000169032
PKACA GeneProduct ncbigene:5566
NFKB GeneProduct ncbigene:4790
CREB GeneProduct ncbigene:1385
CHUK GeneProduct ncbigene:1147
ER GeneProduct ncbigene:2099
TF GeneProduct ncbigene:2099
IKBKB GeneProduct ncbigene:3551
IKBKG GeneProduct ncbigene:8517


  1. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, et al. TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. J Biol Chem. 2006 Mar 24;281(12):7863–72. PubMed Europe PMC Scholia
  2. Song Y-J, Jen K-Y, Soni V, Kieff E, Cahir-McFarland E. IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2689–94. PubMed Europe PMC Scholia
  3. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, et al. Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB. J Leukoc Biol. 2008 Mar;83(3):648–62. PubMed Europe PMC Scholia