Vitamin A and carotenoid metabolism (WP716)

This pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some additional entities (see Waagmeester et al. 2009 []).
last edited


Andra, PaoloRomano, AlexanderPico, MaintBot, Evelo, Susan, Thomas, Khanspers, AllanKuchinsky, Anwesha, Ddigles, Egonw, Mkutmon, Zari, Fehrhart, DeSl, and Eweitz

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Homo sapiens




Pathway Ontology: metabolic pathway of cofactors, vitamins, nutrients vitamin A and metabolites signaling pathway retinol metabolic pathway


Label Type Compact Identifier
Betacarotene Metabolite hmdb:HMDB0000561
Bcmo1 GeneProduct ncbigene:53630
ARAT Protein ncbigene:8694
Rbp7 GeneProduct ncbigene:116362
Aldh1a1 GeneProduct ncbigene:216
RARa GeneProduct ncbigene:5914
Aldh1a2 GeneProduct ncbigene:8854
Abcg8 GeneProduct ncbigene:64241
RetinolVitamin A Metabolite hmdb:HMDB0000305
Rdh12 GeneProduct ncbigene:145226
Rdh5 GeneProduct ncbigene:5959
Dhrs3 GeneProduct ncbigene:9249
Cyp26b1 GeneProduct ncbigene:56603
all-transe 4-oxo RA Metabolite None
Npc1l1 GeneProduct ncbigene:29881
Aldh1a3 GeneProduct ncbigene:220
Aldh1a3 GeneProduct ncbigene:220
Abcg5 GeneProduct ncbigene:64240
11-cis-Retinol Metabolite hmdb:HMDB0006216
Lpl GeneProduct ncbigene:4023
all-trans RetinolVitamin A Metabolite hmdb:HMDB0000305
4-oxo-Retinoic acid Metabolite hmdb:HMDB0006285
Cyp2e1 GeneProduct ncbigene:1571
Beta-Cryptoxanthin Metabolite hmdb:HMDB0002268
RPE65 GeneProduct ncbigene:6121
Bcdo2 GeneProduct ncbigene:83875
MAPK GeneProduct ncbigene:5594
Zeaxanthin Metabolite hmdb:HMDB0002789
Lutein Metabolite hmdb:HMDB0003233
11-cis-Retinal Metabolite hmdb:HMDB0002152
Betacarotene Metabolite hmdb:HMDB0000561
Scarb1 GeneProduct ncbigene:949
Lycopene Metabolite hmdb:HMDB0003000
Retinyl ester Metabolite hmdb:HMDB0003598
Sult2b1 GeneProduct ncbigene:6820
all-trans Retinal Metabolite hmdb:HMDB0001358
Lrat GeneProduct ensembl:ENSG00000121207
All-trans-13,14-dihydroretinol Metabolite hmdb:HMDB0011618
RXRb GeneProduct ncbigene:6257
9-cis-Retinal Metabolite hmdb:HMDB0006218
Rdh10 GeneProduct ncbigene:157506
Retsat GeneProduct ncbigene:54884
Rbp1 GeneProduct ncbigene:5947
Rdh12 GeneProduct ncbigene:145226
RXRa GeneProduct ncbigene:6256
Adh4 GeneProduct ncbigene:127
Vitamin D3 Metabolite hmdb:HMDB0000876
Sult1a1 GeneProduct ncbigene:6817
Cyp26a1 GeneProduct ncbigene:1592
all-trans Retinoic acidVitamin A acid Metabolite hmdb:HMDB0001852
Awat GeneProduct ncbigene:158835
Bcmo1 GeneProduct ncbigene:53630
Cd36 GeneProduct ncbigene:948
Violaxanthin Metabolite hmdb:HMDB0003101
RARg GeneProduct ncbigene:5916
Aldh1a2 GeneProduct ncbigene:8854
13,14 dehydroretinal Metabolite None
Canthaxanthin Metabolite hmdb:HMDB0003154
Scarb1 GeneProduct ncbigene:949
13,14 dehydro RA Metabolite None
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369
Astaxanthin Metabolite hmdb:HMDB0002204
Lrat GeneProduct ensembl:ENSG00000121207
Aldh1a1 GeneProduct ncbigene:216
Rdh5 GeneProduct ncbigene:5959
Rdh8 GeneProduct ncbigene:50700
Adh1 GeneProduct ncbigene:124
RXRg GeneProduct ncbigene:6258
9-cis-Retinol Metabolite hmdb:HMDB0006217
Crabp2 GeneProduct ncbigene:1382
Crabp1 GeneProduct ncbigene:1381
Rlbp1 GeneProduct ncbigene:6017
Alpha-Carotene Metabolite hmdb:HMDB0003993
RetinolVitamin A Metabolite hmdb:HMDB0000305
beta 10 apocorotenal Metabolite None
Betacarotene Metabolite HMDB
Rbp2 GeneProduct Entrez Gene
Retinyl ester Metabolite HMDB
Bcmo1 GeneProduct Entrez Gene
Rbp4 GeneProduct Entrez Gene
RetinalVitamin A aldehyde Metabolite HMDB
Betacarotene Metabolite HMDB
RARb GeneProduct Entrez Gene
Retinol dehydrogenases GeneProduct Entrez Gene


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