Vitamin A and carotenoid metabolism (WP716)

This pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some additional entities (see Waagmeester et al. 2009 [https://www.ncbi.nlm.nih.gov/pubmed/19715393]).
last edited

Authors

Andra, PaoloRomano, AlexanderPico, MaintBot, Evelo, Susan, Thomas, Khanspers, AllanKuchinsky, Anwesha, Ddigles, Egonw, Mkutmon, Zari, Fehrhart, DeSl, and Eweitz

Cited In

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Organism

Homo sapiens

Communities

Micronutrients

Annotations

Pathway Ontology: metabolic pathway of cofactors, vitamins, nutrients vitamin A and metabolites signaling pathway retinol metabolic pathway

Participants

Label Type Compact Identifier
Betacarotene Metabolite hmdb:HMDB0000561
Bcmo1 GeneProduct ncbigene:53630
ARAT Protein ncbigene:8694
Rbp7 GeneProduct ncbigene:116362
Aldh1a1 GeneProduct ncbigene:216
RARa GeneProduct ncbigene:5914
Aldh1a2 GeneProduct ncbigene:8854
Abcg8 GeneProduct ncbigene:64241
RetinolVitamin A Metabolite hmdb:HMDB0000305
Rdh12 GeneProduct ncbigene:145226
Rdh5 GeneProduct ncbigene:5959
Dhrs3 GeneProduct ncbigene:9249
Cyp26b1 GeneProduct ncbigene:56603
all-transe 4-oxo RA Metabolite None
Npc1l1 GeneProduct ncbigene:29881
Aldh1a3 GeneProduct ncbigene:220
Aldh1a3 GeneProduct ncbigene:220
Abcg5 GeneProduct ncbigene:64240
11-cis-Retinol Metabolite hmdb:HMDB0006216
Lpl GeneProduct ncbigene:4023
all-trans RetinolVitamin A Metabolite hmdb:HMDB0000305
4-oxo-Retinoic acid Metabolite hmdb:HMDB0006285
Cyp2e1 GeneProduct ncbigene:1571
Beta-Cryptoxanthin Metabolite hmdb:HMDB0002268
RPE65 GeneProduct ncbigene:6121
Bcdo2 GeneProduct ncbigene:83875
MAPK GeneProduct ncbigene:5594
Zeaxanthin Metabolite hmdb:HMDB0002789
Lutein Metabolite hmdb:HMDB0003233
11-cis-Retinal Metabolite hmdb:HMDB0002152
Betacarotene Metabolite hmdb:HMDB0000561
Scarb1 GeneProduct ncbigene:949
Lycopene Metabolite hmdb:HMDB0003000
Retinyl ester Metabolite hmdb:HMDB0003598
Sult2b1 GeneProduct ncbigene:6820
all-trans Retinal Metabolite hmdb:HMDB0001358
Lrat GeneProduct ensembl:ENSG00000121207
All-trans-13,14-dihydroretinol Metabolite hmdb:HMDB0011618
RXRb GeneProduct ncbigene:6257
9-cis-Retinal Metabolite hmdb:HMDB0006218
Rdh10 GeneProduct ncbigene:157506
Retsat GeneProduct ncbigene:54884
Rbp1 GeneProduct ncbigene:5947
Rdh12 GeneProduct ncbigene:145226
RXRa GeneProduct ncbigene:6256
Adh4 GeneProduct ncbigene:127
Vitamin D3 Metabolite hmdb:HMDB0000876
Sult1a1 GeneProduct ncbigene:6817
Cyp26a1 GeneProduct ncbigene:1592
all-trans Retinoic acidVitamin A acid Metabolite hmdb:HMDB0001852
Awat GeneProduct ncbigene:158835
Bcmo1 GeneProduct ncbigene:53630
Cd36 GeneProduct ncbigene:948
Violaxanthin Metabolite hmdb:HMDB0003101
RARg GeneProduct ncbigene:5916
Aldh1a2 GeneProduct ncbigene:8854
13,14 dehydroretinal Metabolite None
Canthaxanthin Metabolite hmdb:HMDB0003154
Scarb1 GeneProduct ncbigene:949
13,14 dehydro RA Metabolite None
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369
Astaxanthin Metabolite hmdb:HMDB0002204
Lrat GeneProduct ensembl:ENSG00000121207
Aldh1a1 GeneProduct ncbigene:216
Rdh5 GeneProduct ncbigene:5959
Rdh8 GeneProduct ncbigene:50700
Adh1 GeneProduct ncbigene:124
RXRg GeneProduct ncbigene:6258
9-cis-Retinol Metabolite hmdb:HMDB0006217
Crabp2 GeneProduct ncbigene:1382
Crabp1 GeneProduct ncbigene:1381
Rlbp1 GeneProduct ncbigene:6017
Alpha-Carotene Metabolite hmdb:HMDB0003993
RetinolVitamin A Metabolite hmdb:HMDB0000305
beta 10 apocorotenal Metabolite None
Betacarotene Metabolite HMDB
Rbp2 GeneProduct Entrez Gene
Retinyl ester Metabolite HMDB
Bcmo1 GeneProduct Entrez Gene
Rbp4 GeneProduct Entrez Gene
RetinalVitamin A aldehyde Metabolite HMDB
Betacarotene Metabolite HMDB
RARb GeneProduct Entrez Gene
Retinol dehydrogenases GeneProduct Entrez Gene
None

References

  1. Khachik F, Beecher GR, Goli MB, Lusby WR, Smith JC Jr. Separation and identification of carotenoids and their oxidation products in the extracts of human plasma. Anal Chem. 1992 Sep 15;64(18):2111–22. PubMed Europe PMC Scholia
  2. Sies H, Stahl W, Sundquist AR. Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids. Ann N Y Acad Sci. 1992 Sep 30;669:7–20. PubMed Europe PMC Scholia
  3. Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, et al. Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men. Am J Clin Nutr. 1992 Jun;55(6):1120–5. PubMed Europe PMC Scholia
  4. Bendich A, Olson JA. Biological actions of carotenoids. FASEB J. 1989 Jun;3(8):1927–32. PubMed Europe PMC Scholia
  5. Hidiroglou M, Williams CJ. Interrelationships among liposoluble vitamins in ruminants. Am J Vet Res. 1986 Aug;47(8):1767–71. PubMed Europe PMC Scholia
  6. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG. Carotenoids in the human macula and whole retina. Invest Ophthalmol Vis Sci. 1988 Jun;29(6):850–5. PubMed Europe PMC Scholia
  7. Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E. Seasonal and sex-related variations in six serum carotenoids, retinol, and alpha-tocopherol. Am J Clin Nutr. 1994 Jul;60(1):106–10. PubMed Europe PMC Scholia
  8. Boosalis MG, Snowdon DA, Tully CL, Gross MD. Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study. Nutrition. 1996;12(7–8):475–8. PubMed Europe PMC Scholia
  9. VandenLangenberg GM, Brady WE, Nebeling LC, Block G, Forman M, Bowen PE, et al. Influence of using different sources of carotenoid data in epidemiologic studies. J Am Diet Assoc. 1996 Dec;96(12):1271–5. PubMed Europe PMC Scholia
  10. Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL. Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis. Eur J Pediatr. 1997 Dec;156(12):949–51. PubMed Europe PMC Scholia
  11. Törmä H, Rollman O, Binderup L, Michaelsson G. Vitamin D analogs affect the uptake and metabolism of retinol by human epidermal keratinocytes in culture. J Investig Dermatol Symp Proc. 1996 Apr;1(1):49–53. PubMed Europe PMC Scholia
  12. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, et al. Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. Nutr Cancer. 1999;33(1):105–12. PubMed Europe PMC Scholia
  13. Johansson S, Melhus H. Vitamin A antagonizes calcium response to vitamin D in man. J Bone Miner Res. 2001 Oct;16(10):1899–905. PubMed Europe PMC Scholia
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  15. Ruhl CE, Everhart JE. Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States. Gastroenterology. 2003 Jun;124(7):1821–9. PubMed Europe PMC Scholia
  16. Czeczuga-Semeniuk E, Wołczyński S, Markiewicz W. Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue. Neoplasma. 2003;50(4):280–6. PubMed Europe PMC Scholia
  17. Sun Y, Ng L, Lam W, Lo CK-C, Chan P-T, Yuen Y-L, et al. Identification and characterization of a novel mouse peroxisome proliferator-activated receptor alpha-regulated and starvation-induced gene, Ppsig. Int J Biochem Cell Biol. 2008;40(9):1775–91. PubMed Europe PMC Scholia
  18. Waagmeester A, Pezik P, Coort S, Tourniaire F, Evelo C, Rebholz-Schuhmann D. Pathway enrichment based on text mining and its validation on carotenoid and vitamin A metabolism. OMICS. 2009 Oct;13(5):367–79. PubMed Europe PMC Scholia