Monoamine transport (WP727)

Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP727 CPTAC Assay Portal]
last edited

Authors

Bzhang, MaintBot, Dex duncan, Khanspers, AlexanderPico, Ddigles, Zari, MirellaKalafati, Mkutmon, DeSl, Egonw, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: monoamine transport pathway regulatory pathway

Participants

Label Type Compact Identifier
TSC2 GeneProduct ncbigene:7249
SCAMP2 GeneProduct ncbigene:10066
RBL2 GeneProduct ncbigene:5934
AMPH GeneProduct ncbigene:273
HEPES Metabolite cas:7365-45-9
STX1A GeneProduct ncbigene:6804
SYN1 GeneProduct ncbigene:6853
reserpine Metabolite cas:50-55-5
noradrenaline Metabolite cas:51-41-2
anisomycin Metabolite chebi:338412
PVRL2 GeneProduct ncbigene:5819
TNF GeneProduct ncbigene:7124
SLC5A7 GeneProduct ncbigene:60482
FBXO32 GeneProduct ncbigene:114907
SLC6A2 GeneProduct ncbigene:6530
ITGB3 GeneProduct ncbigene:3690
SB 203580 Metabolite cas:152121-47-6
CDC25C GeneProduct ncbigene:995
NOS1 GeneProduct ncbigene:4842
ACHE GeneProduct ncbigene:43
dopamine Metabolite cas:51-61-6
epinephrine Metabolite cas:51-43-4
DBH GeneProduct ncbigene:1621
TDO2 GeneProduct ncbigene:6999
4-Aminobutanoic acid Metabolite cas:56-12-2
TNFRSF11B GeneProduct ncbigene:4982
catecholamines Metabolite chebi:33567
AGT GeneProduct ncbigene:183
SLC6A3 GeneProduct ncbigene:6531
serotonin Metabolite cas:50-67-9
TPH2 GeneProduct ncbigene:121278
Hemicholinium-3 Metabolite cas:312-45-8
HRH3 GeneProduct ncbigene:11255
MAPK14 GeneProduct ncbigene:1432
TGFB1I1 GeneProduct ncbigene:7041
Phorbol ester Metabolite cas:16561-29-8
SLC6A1 GeneProduct ncbigene:6529
IL1R1 GeneProduct ncbigene:3554
citalopram Metabolite cas:59729-33-8
UNC13B GeneProduct ncbigene:10497
L-tryptophan Metabolite cas:73-22-3
ADORA2A GeneProduct ncbigene:135
TH GeneProduct ncbigene:7054
PPP2CB GeneProduct ncbigene:5516
IL1B GeneProduct ncbigene:3553
SLC6A4 GeneProduct ncbigene:6532

References

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  2. Tamminga CA, Nemeroff CB, Blakely RD, Brady L, Carter CS, Davis KL, et al. Developing novel treatments for mood disorders: accelerating discovery. Biol Psychiatry. 2002 Sep 15;52(6):589–609. PubMed Europe PMC Scholia
  3. Sung U, Apparsundaram S, Galli A, Kahlig KM, Savchenko V, Schroeter S, et al. A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity. J Neurosci. 2003 Mar 1;23(5):1697–709. PubMed Europe PMC Scholia
  4. Hahn MK, Robertson D, Blakely RD. A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters. J Neurosci. 2003 Jun 1;23(11):4470–8. PubMed Europe PMC Scholia
  5. Miner LH, Schroeter S, Blakely RD, Sesack SR. Ultrastructural localization of the norepinephrine transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to probable dopamine terminals. J Comp Neurol. 2003 Nov 24;466(4):478–94. PubMed Europe PMC Scholia
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  10. Zhu C-B, Carneiro AM, Dostmann WR, Hewlett WA, Blakely RD. p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process. J Biol Chem. 2005 Apr 22;280(16):15649–58. PubMed Europe PMC Scholia
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  14. Miner LH, Jedema HP, Moore FW, Blakely RD, Grace AA, Sesack SR. Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex. J Neurosci. 2006 Feb 1;26(5):1571–8. PubMed Europe PMC Scholia
  15. Zhu C-B, Blakely RD, Hewlett WA. The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters. Neuropsychopharmacology. 2006 Oct;31(10):2121–31. PubMed Europe PMC Scholia
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  19. Hahn MK, Blakely RD. The functional impact of SLC6 transporter genetic variation. Annu Rev Pharmacol Toxicol. 2007;47:401–41. PubMed Europe PMC Scholia
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  23. Steiner JA, Carneiro AMD, Blakely RD. Going with the flow: trafficking-dependent and -independent regulation of serotonin transport. Traffic. 2008 Sep;9(9):1393–402. PubMed Europe PMC Scholia
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  25. Hoard JL, Hoover DB, Mabe AM, Blakely RD, Feng N, Paolocci N. Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75. Neuroscience. 2008 Sep 22;156(1):129–42. PubMed Europe PMC Scholia
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