Toll-like receptor signaling pathway (WP75)

Toll-like receptors (TLRs) are a critical part of the innate immune response, and are expressed on macrophages and dendritic cells. TLRs are pattern-recognition receptors, and recognize molecules derived from microbes. Once activated, TLRs result in activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NFkB and MAPK; and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NFkB and MAPK. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal].
last edited


Jmboer, MaintBot, Thomas, AlexanderPico, Khanspers, Lizezhong, Egonw, Mkutmon, Jmelius, DeSl, Eweitz, and Finterly

Cited In


Homo sapiens



Pathway Ontology: signaling pathway pertinent to immunity Toll-like receptor signaling pathway


Label Type Compact Identifier
Imidazoquinolin Metabolite chemspider:14697812
LY96 GeneProduct ncbigene:23643
MAPK12 GeneProduct ncbigene:6300
Complement and coagulation cascades Pathway wikipathways:WP558
IRAK1 GeneProduct ncbigene:3654
Zymosan (Yeast) Metabolite chebi:37671
CD80 GeneProduct ncbigene:941
LPS (Gram negative) Metabolite chebi:52603
IFNA10 GeneProduct ncbigene:3446
TLR1 GeneProduct ncbigene:7096
TIRAP GeneProduct ncbigene:114609
TLR9 GeneProduct ncbigene:54106
STAT1 GeneProduct ncbigene:6772
IRAK4 GeneProduct ncbigene:51135
TLR5 GeneProduct ncbigene:7100
PIK3R1 GeneProduct ncbigene:5295
NFKB1 GeneProduct ncbigene:4790
TICAM1 GeneProduct ncbigene:148022
IFNA8 GeneProduct ncbigene:3445
MAPK14 GeneProduct ncbigene:1432
TRAF6 GeneProduct ncbigene:7189
AKT2 GeneProduct ncbigene:208
CCL5 GeneProduct ncbigene:6352
TOLLIP GeneProduct ncbigene:54472
IL12B GeneProduct ncbigene:3593
PIK3CB GeneProduct ncbigene:5291
PIK3CG GeneProduct ncbigene:5294
IFNA16 GeneProduct ncbigene:3449
TRAF3 GeneProduct ncbigene:7187
TLR6 GeneProduct ncbigene:10333
PI3K-Akt SignalingPathway Pathway wikipathways:WP4172
MAPK10 GeneProduct ncbigene:5602
Peptidoglycan(Gram positive) Metabolite chebi:8005
PIK3R5 GeneProduct ncbigene:23533
IFNA2 GeneProduct ncbigene:3440
CHUK GeneProduct ncbigene:1147
TBK1 GeneProduct ncbigene:29110
AKT3 GeneProduct ncbigene:10000
TAB2 GeneProduct ncbigene:23118
IL12A GeneProduct ncbigene:3592
IFNA7 GeneProduct ncbigene:3444
IFNA21 GeneProduct ncbigene:3452
TRAF6 GeneProduct ncbigene:7189
TNF GeneProduct ncbigene:7124
CD40 GeneProduct ncbigene:958
IFNA17 GeneProduct ncbigene:3451
CASP8 GeneProduct ncbigene:841
Lipopolysaccharidebiosynthesis Pathway None
TIRAP GeneProduct ncbigene:114609
MAPK signaling pathway Pathway wikipathways:WP382
SPP1 GeneProduct ncbigene:6696
CCL3 GeneProduct ncbigene:6348
TLR2 GeneProduct ncbigene:7097
CXCL10 GeneProduct ncbigene:3627
TLR4 GeneProduct ncbigene:7099
Ubiquitin mediated proteolysis Pathway None
IFNA14 GeneProduct ncbigene:3448
TLR7 GeneProduct ncbigene:51284
IFNA4 GeneProduct ncbigene:3441
IKBKE GeneProduct ncbigene:9641
IFNA1 GeneProduct ncbigene:3439
MyD88-independent pathway Pathway None
IRF7 GeneProduct ncbigene:3665
MAP2K4 GeneProduct ncbigene:6416
IL1B GeneProduct ncbigene:3553
Cytokine-receptor interaction Pathway wikipathways:WP530
MYD88 GeneProduct ncbigene:4615
IRAK1 GeneProduct ncbigene:3654
TLR8 GeneProduct ncbigene:51311
MAP3K7 GeneProduct ncbigene:6885
TICAM2 GeneProduct ncbigene:353376
IRF3 GeneProduct ncbigene:3661
IL6 GeneProduct ncbigene:3569
CD86 GeneProduct ncbigene:942
MAPK3 GeneProduct ncbigene:5595
IRAK4 GeneProduct ncbigene:51135
PIK3CD GeneProduct ncbigene:5293
MAPK13 GeneProduct ncbigene:5603
IFNA13 GeneProduct ncbigene:3447
CD14 GeneProduct ncbigene:929
IFNB1 GeneProduct ncbigene:3456
IFNAR1 GeneProduct ncbigene:3454
MYD88 GeneProduct ncbigene:4615
MAPK8 GeneProduct ncbigene:5599
RIPK1 GeneProduct ncbigene:8737
LBP GeneProduct ncbigene:3929
MYD88 GeneProduct ncbigene:4615
IRF5 GeneProduct ncbigene:3663
TAB1 GeneProduct ncbigene:10454
MyD88-dependent pathway Pathway None
IL8 GeneProduct ncbigene:3576
MAPK1 GeneProduct ncbigene:5594
MAP2K1 GeneProduct ncbigene:5604
FADD GeneProduct ncbigene:8772
IFNB1 GeneProduct ncbigene:3456
MAP2K2 GeneProduct ncbigene:5605
IFNAR2 GeneProduct ncbigene:3455
TRAF6 GeneProduct ncbigene:7189
IFNA5 GeneProduct ncbigene:3442
PIK3R3 GeneProduct ncbigene:8503
MYD88 GeneProduct ncbigene:4615
MAP3K8 GeneProduct ncbigene:1326
RAC1 GeneProduct ncbigene:5879
TLR2 GeneProduct ncbigene:7097
PIK3R2 GeneProduct ncbigene:5296
MAP2K7 GeneProduct ncbigene:5609
CXCL9 GeneProduct ncbigene:4283
TLR3 GeneProduct ncbigene:7098
IFNA6 GeneProduct ncbigene:3443
AKT1 GeneProduct ncbigene:207
MAPK11 GeneProduct ncbigene:5600
Lipoprotein particle Metabolite chebi:6495
CCL4 GeneProduct ncbigene:6351
Apoptosis Pathway wikipathways:WP254
Type II interferon signaling (IFNG) Pathway wikipathways:WP619
Flagellar assembly Pathway None
FOS GeneProduct ncbigene:2353
PIK3CA GeneProduct ncbigene:5290
CXCL11 GeneProduct ncbigene:6373
Lipoarabinomannans(Mycobacteria) Metabolite chebi:59524
MAPK9 GeneProduct ncbigene:5601
TAB3 GeneProduct ncbigene:257397
IKBKG GeneProduct ensembl:ENSG00000269335
IKBKB GeneProduct ensembl:ENSG00000104365
CHUK GeneProduct ensembl:ENSG00000213341
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ensembl:ENSG00000173039
NFKBIA GeneProduct ensembl:ENSG00000100906
NFKBIB GeneProduct ensembl:ENSG00000104825
NFKBIA GeneProduct ensembl:ENSG00000100906
NFKBIB GeneProduct ensembl:ENSG00000104825
NFKBIA GeneProduct ensembl:ENSG00000100906
NFKBIB GeneProduct ensembl:ENSG00000104825
JUN GeneProduct ncbigene:3725
MAP2K3 GeneProduct ncbigene:5606
MAP2K6 GeneProduct ncbigene:5608