Insulin signaling (WP966)

Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentation.
last edited

Authors

MaintBot, Zari, Mkutmon, and Eweitz

Cited In

Organism

Bos taurus

Communities

Annotations

Pathway Ontology: insulin signaling pathway

Participants

Label Type Compact Identifier
STXBP2 GeneProduct ensembl:ENSBTAG00000009178
PIK3CD GeneProduct ensembl:ENSBTAG00000018984
PIK3C3 GeneProduct ensembl:ENSBTAG00000026290
CYTH3 GeneProduct ensembl:ENSBTAG00000007384
PTPRF GeneProduct ensembl:ENSBTAG00000000253
RAC1 GeneProduct ensembl:ENSBTAG00000009233
GSK3B GeneProduct ensembl:ENSBTAG00000048057
PTP GeneProduct None
MINK1 GeneProduct ensembl:ENSBTAG00000004907
GRB2 GeneProduct ensembl:ENSBTAG00000004736
SHC3 GeneProduct ensembl:ENSBTAG00000011375
IRS1 GeneProduct ensembl:ENSBTAG00000021308
SLC2A1 GeneProduct ensembl:ENSBTAG00000009617
RPS6KA4 GeneProduct ensembl:ENSBTAG00000039153
IKBKB GeneProduct ensembl:ENSBTAG00000007599
MAP4K4 GeneProduct ensembl:ENSBTAG00000013023
SOCS3 GeneProduct ensembl:ENSBTAG00000008441
PRKCH GeneProduct ensembl:ENSBTAG00000003276
KIF5B GeneProduct ensembl:ENSBTAG00000002280
IRS1 GeneProduct ensembl:ENSBTAG00000021308
EHD2 GeneProduct ensembl:ENSBTAG00000021191
ARF6 GeneProduct ensembl:ENSBTAG00000045980
GYG1 GeneProduct ensembl:ENSBTAG00000001721
AKT2 GeneProduct ensembl:ENSBTAG00000001400
SRF GeneProduct ensembl:ENSBTAG00000012777
MAP3K2 GeneProduct ensembl:ENSBTAG00000004216
RAB4A GeneProduct ensembl:ENSBTAG00000018857
PRKCD GeneProduct ensembl:ENSBTAG00000008719
AKT1 GeneProduct ensembl:ENSBTAG00000017636
CAP1 GeneProduct ensembl:ENSBTAG00000013363
RHEB GeneProduct ensembl:ENSBTAG00000031861
PFKM GeneProduct ensembl:ENSBTAG00000000286
STXBP1 GeneProduct ensembl:ENSBTAG00000003525
PIK3R3 GeneProduct None
MAPK12 GeneProduct ensembl:ENSBTAG00000019574
PIK3R1 GeneProduct ensembl:ENSBTAG00000010989
MAP3K5 GeneProduct ensembl:ENSBTAG00000009065
IRS2 GeneProduct ensembl:ENSBTAG00000012019
PIK3C2G GeneProduct ensembl:ENSBTAG00000020715
PIK3R2 GeneProduct ensembl:ENSBTAG00000002350
MAPK10 GeneProduct ensembl:ENSBTAG00000020048
MAP3K3 GeneProduct ensembl:ENSBTAG00000008151
MAP4K1 GeneProduct ensembl:ENSBTAG00000021145
MAPK3 GeneProduct ensembl:ENSBTAG00000016156
RPS6KA3 GeneProduct ensembl:ENSBTAG00000017639
PTEN GeneProduct ensembl:ENSBTAG00000009498
ELK1 GeneProduct ensembl:ENSBTAG00000015817
SHC1 GeneProduct ensembl:ENSBTAG00000019838
CRK GeneProduct ensembl:ENSBTAG00000005665
TRIB3 GeneProduct ensembl:ENSBTAG00000017007
STXBP4 GeneProduct ensembl:ENSBTAG00000018713
RPS6KA6 GeneProduct ensembl:ENSBTAG00000002015
INSR GeneProduct ensembl:ENSBTAG00000012687
XBP1 GeneProduct ensembl:ENSBTAG00000005970
FOXO1 GeneProduct ensembl:ENSBTAG00000044105
EIF4EBP1 GeneProduct ensembl:ENSBTAG00000027654
TBC1D4 GeneProduct ensembl:ENSBTAG00000005760
PRKCB GeneProduct ensembl:ENSBTAG00000020921
MAP2K7 GeneProduct ensembl:ENSBTAG00000010639
RPS6KB2 GeneProduct ensembl:ENSBTAG00000009175
SOS1 GeneProduct ensembl:ENSBTAG00000011643
RAC2 GeneProduct ensembl:ENSBTAG00000011043
FOS GeneProduct ensembl:ENSBTAG00000004322
PIK3CG GeneProduct ensembl:ENSBTAG00000020848
RRAD GeneProduct ensembl:ENSBTAG00000013929
PIK3CA GeneProduct ensembl:ENSBTAG00000009232
IRS4 GeneProduct ensembl:ENSBTAG00000006535
SGK3 GeneProduct ensembl:ENSBTAG00000013284
SH2B2 GeneProduct ensembl:ENSBTAG00000009691
MAPK13 GeneProduct ensembl:ENSBTAG00000010007
GYS1 GeneProduct ensembl:ENSBTAG00000039958
TSC2 GeneProduct ensembl:ENSBTAG00000020617
PIK3CB GeneProduct ensembl:ENSBTAG00000006909
EHD1 GeneProduct ensembl:ENSBTAG00000007361
MAP3K1 GeneProduct ensembl:ENSBTAG00000013790
MAP4K3 GeneProduct ensembl:ENSBTAG00000016442
ENPP1 GeneProduct ensembl:ENSBTAG00000021830
MAP2K6 GeneProduct ensembl:ENSBTAG00000001609
ARHGAP33 GeneProduct ensembl:ENSBTAG00000009714
SLC2A4 GeneProduct ensembl:ENSBTAG00000009190
MAP3K8 GeneProduct ensembl:ENSBTAG00000011600
PFKL GeneProduct ensembl:ENSBTAG00000010658
TSC1 GeneProduct ensembl:ENSBTAG00000005190
MAP3K12 GeneProduct ensembl:ENSBTAG00000020758
RPS6KA5 GeneProduct ensembl:ENSBTAG00000010906
STX4 GeneProduct ensembl:ENSBTAG00000007523
IGF1R GeneProduct ensembl:ENSBTAG00000021527
PRKCZ GeneProduct ensembl:ENSBTAG00000014119
SNAP25 GeneProduct ensembl:ENSBTAG00000008323
MAP2K4 GeneProduct ensembl:ENSBTAG00000012103
GRB14 GeneProduct ensembl:ENSBTAG00000019291
PRKCQ GeneProduct ensembl:ENSBTAG00000010664
RPS6KA1 GeneProduct ensembl:ENSBTAG00000014447
MAPK7 GeneProduct ensembl:ENSBTAG00000001014
RPS6KA2 GeneProduct ensembl:ENSBTAG00000021741
MAPK14 GeneProduct ensembl:ENSBTAG00000020783
RPS6KB1 GeneProduct ensembl:ENSBTAG00000016851
RHOQ GeneProduct ensembl:ENSBTAG00000013749
MAP3K11 GeneProduct ensembl:ENSBTAG00000004114
PRKAA2 GeneProduct ensembl:ENSBTAG00000018747
SNAP23 GeneProduct ensembl:ENSBTAG00000005661
PTPN1 GeneProduct ensembl:ENSBTAG00000006616
MAPK8 GeneProduct ensembl:ENSBTAG00000007876
INPPL1 GeneProduct ensembl:ENSBTAG00000019167
CBLB GeneProduct ensembl:ENSBTAG00000013057
MAP3K7 GeneProduct ensembl:ENSBTAG00000002625
STXBP3 GeneProduct ensembl:ENSBTAG00000007330
INPP4A GeneProduct ensembl:ENSBTAG00000004814
SGK1 GeneProduct ensembl:ENSBTAG00000004269
CBL GeneProduct ensembl:ENSBTAG00000006817
PIK3R4 GeneProduct ensembl:ENSBTAG00000020787
MAPK11 GeneProduct ensembl:ENSBTAG00000030182
MAPK9 GeneProduct ensembl:ENSBTAG00000004709
PTPN11 GeneProduct ensembl:ENSBTAG00000002048
GYS2 GeneProduct ensembl:ENSBTAG00000013333
JUN GeneProduct ensembl:ENSBTAG00000004037
SOCS1 GeneProduct ensembl:ENSBTAG00000004386
MAPK6 GeneProduct ensembl:ENSBTAG00000005865
EIF4E GeneProduct ensembl:ENSBTAG00000009522
SHC2 GeneProduct ensembl:ENSBTAG00000016072
FLOT2 GeneProduct ensembl:ENSBTAG00000010073
CBLC GeneProduct ensembl:ENSBTAG00000009494
MYO1C GeneProduct ensembl:ENSBTAG00000001332
GAB1 GeneProduct ensembl:ENSBTAG00000002813
RHOJ GeneProduct ensembl:ENSBTAG00000017200
GSK3A GeneProduct ensembl:ENSBTAG00000020756
PRKCI GeneProduct ensembl:ENSBTAG00000001403
PRKAA1 GeneProduct ensembl:ENSBTAG00000000013
SORBS1 GeneProduct ensembl:ENSBTAG00000002880
SOS2 GeneProduct ensembl:ENSBTAG00000005550
MAP3K13 GeneProduct ensembl:ENSBTAG00000017103
PPP1R3A GeneProduct ensembl:ENSBTAG00000006733
RAF1 GeneProduct ensembl:ENSBTAG00000004514
ARF1 GeneProduct ensembl:ENSBTAG00000007725
MTOR GeneProduct ensembl:ENSBTAG00000015325
PRKCA GeneProduct ensembl:ENSBTAG00000001061
LIPE GeneProduct ensembl:ENSBTAG00000038321
MAP2K3 GeneProduct ensembl:ENSBTAG00000010576
MAPK4 GeneProduct ensembl:ENSBTAG00000009907
MAP4K2 GeneProduct ensembl:ENSBTAG00000001037
PDPK1 GeneProduct ensembl:ENSBTAG00000034436
HRAS GeneProduct ensembl:ENSBTAG00000046644
RAPGEF1 GeneProduct ensembl:ENSBTAG00000020791
FOXO3 GeneProduct ensembl:ENSBTAG00000011234
MAP2K5 GeneProduct ensembl:ENSBTAG00000000218
GRB10 GeneProduct ensembl:ENSBTAG00000017086
EGR1 GeneProduct ensembl:ENSBTAG00000010069
MAP3K10 GeneProduct ensembl:ENSBTAG00000017618
VAMP2 GeneProduct ensembl:ENSBTAG00000003891
PIK3C2A GeneProduct ensembl:ENSBTAG00000004901
MAPK1 GeneProduct ensembl:ENSBTAG00000010312
FLOT1 GeneProduct ensembl:ENSBTAG00000009960
PIK3CA GeneProduct ensembl:ENSBTAG00000009232
MAP2K1 GeneProduct ensembl:ENSBTAG00000033983
MAP3K6 GeneProduct ensembl:ENSBTAG00000010254
SGK2 GeneProduct ensembl:ENSBTAG00000021033
MAP3K4 GeneProduct ensembl:ENSBTAG00000020079
MAP3K9 GeneProduct ensembl:ENSBTAG00000005700
KIF3A GeneProduct ensembl:ENSBTAG00000025477
MAP4K5 GeneProduct ensembl:ENSBTAG00000014792
MAP2K2 GeneProduct ensembl:ENSBTAG00000024450
MAPK8 GeneProduct ensembl:ENSBTAG00000007876
MAP3K14 GeneProduct ensembl:ENSBTAG00000007084

References

  1. Quon MJ, Campfield LA. A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation. J Theor Biol. 1991 May 7;150(1):93–107. PubMed Europe PMC Scholia
  2. Bevan P. Insulin signalling. J Cell Sci. 2001 Apr;114(Pt 8):1429–30. PubMed Europe PMC Scholia
  3. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001 Dec 13;414(6865):799–806. PubMed Europe PMC Scholia